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Sleeping sickness: An agent-based model approach

Author

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  • Correia, Matheus M.G.
  • Barboza, João V.M.
  • Espíndola, Aquino L.

Abstract

In this work we study the transmission of Trypanosoma brucei gambiense (Tbg), which causes the Human African Trypanosomiasis, also known as sleeping sickness disease, very common in African rural areas. Simulations were implemented using agent-based modeling approach, where agents were split into three groups: humans, animals and flies. Humans and animals are the reservoirs for the trypanosoma and the interaction between them (transmission of the pathogen), depends exclusively on the third group, the disease vector, the tsetse fly. We applied a type of treatment based on the drug Fexinidazole in different percentages for the human population, aiming the optimization of treatment resources to minimize costs and maximize the efficacy of this new drug in rural zones of the Democratic Republic of the Congo (DRC). Simulations of different scenarios show that the disease eradication is possible depending on the available resources (medication, health team) to be used.

Suggested Citation

  • Correia, Matheus M.G. & Barboza, João V.M. & Espíndola, Aquino L., 2021. "Sleeping sickness: An agent-based model approach," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 582(C).
    • Handle: RePEc:eee:phsmap:v:582:y:2021:i:c:s0378437121005550
    DOI: 10.1016/j.physa.2021.126282
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    References listed on IDEAS

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    1. Anirban Chakraborti & Damien Challet & Arnab Chatterjee & Matteo Marsili & Yi-Cheng Zhang & Bikas K. Chakrabarti, 2013. "Statistical Mechanics of Competitive Resource Allocation using Agent-based Models," Papers 1305.2121, arXiv.org, revised Sep 2014.
    2. Anirban Chakraborti & Damien Challet & Arnab Chatterjee & Matteo Marsili & Yi-Cheng Zhang & Bikas K. Chakrabarti, 2013. "Statistical Mechanics of Competitive Resource Allocation using Agent-based Models," Papers 1305.2121, arXiv.org, revised Sep 2014.
    3. Yasmine Samia & Alison Kealey & Robert J. Smith?, 2016. "A mathematical model of a theoretical sleeping sickness vaccine," Mathematical Population Studies, Taylor & Francis Journals, vol. 23(2), pages 95-122, April.
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