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Evolution of gene regulatory networks: Robustness as an emergent property of evolution

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  • Krishnan, Arun
  • Tomita, Masaru
  • Giuliani, Alessandro

Abstract

Gene Regulatory Networks (GRNs) have become a major focus of interest in recent years. Although much work has been done in elucidating the transcriptional regulatory network, the underlying mechanisms that have possibly influenced the evolution of these GRNs are still debatable. We have developed a framework to analyze the effect of objective functions, input types and starting populations on the evolution of GRNs with a specific emphasis on the robustness of evolved GRNs.

Suggested Citation

  • Krishnan, Arun & Tomita, Masaru & Giuliani, Alessandro, 2008. "Evolution of gene regulatory networks: Robustness as an emergent property of evolution," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 387(8), pages 2170-2186.
    • Handle: RePEc:eee:phsmap:v:387:y:2008:i:8:p:2170-2186
    DOI: 10.1016/j.physa.2007.11.022
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    References listed on IDEAS

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