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Practical estimation of high dimensional stochastic differential mixed-effects models

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  • Picchini, Umberto
  • Ditlevsen, Susanne

Abstract

Stochastic differential equations (SDEs) are established tools for modeling physical phenomena whose dynamics are affected by random noise. By estimating parameters of an SDE, intrinsic randomness of a system around its drift can be identified and separated from the drift itself. When it is of interest to model dynamics within a given population, i.e. to model simultaneously the performance of several experiments or subjects, mixed-effects modelling allows for the distinction of between and within experiment variability. A framework for modeling dynamics within a population using SDEs is proposed, representing simultaneously several sources of variation: variability between experiments using a mixed-effects approach and stochasticity in the individual dynamics, using SDEs. These stochastic differential mixed-effects models have applications in e.g. pharmacokinetics/pharmacodynamics and biomedical modelling. A parameter estimation method is proposed and computational guidelines for an efficient implementation are given. Finally the method is evaluated using simulations from standard models like the two-dimensional Ornstein-Uhlenbeck (OU) and the square root models.

Suggested Citation

  • Picchini, Umberto & Ditlevsen, Susanne, 2011. "Practical estimation of high dimensional stochastic differential mixed-effects models," Computational Statistics & Data Analysis, Elsevier, vol. 55(3), pages 1426-1444, March.
    • Handle: RePEc:eee:csdana:v:55:y:2011:i:3:p:1426-1444
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    1. Comte, F. & Genon-Catalot, V. & Samson, A., 2013. "Nonparametric estimation for stochastic differential equations with random effects," Stochastic Processes and their Applications, Elsevier, vol. 123(7), pages 2522-2551.
    2. Delattre, Maud & Genon-Catalot, Valentine & Larédo, Catherine, 2018. "Parametric inference for discrete observations of diffusion processes with mixed effects," Stochastic Processes and their Applications, Elsevier, vol. 128(6), pages 1929-1957.
    3. Oscar García, 2019. "Estimating reducible stochastic differential equations by conversion to a least-squares problem," Computational Statistics, Springer, vol. 34(1), pages 23-46, March.
    4. Fabienne Comte & Nicolas Marie, 2021. "Nonparametric estimation for I.I.D. paths of fractional SDE," Statistical Inference for Stochastic Processes, Springer, vol. 24(3), pages 669-705, October.
    5. Charlotte Dion, 2016. "Nonparametric estimation in a mixed-effect Ornstein–Uhlenbeck model," Metrika: International Journal for Theoretical and Applied Statistics, Springer, vol. 79(8), pages 919-951, November.
    6. Mohammadi, Neda & Santoro, Leonardo V. & Panaretos, Victor M., 2024. "Nonparametric estimation for SDE with sparsely sampled paths: An FDA perspective," Stochastic Processes and their Applications, Elsevier, vol. 167(C).
    7. Wiqvist, Samuel & Golightly, Andrew & McLean, Ashleigh T. & Picchini, Umberto, 2021. "Efficient inference for stochastic differential equation mixed-effects models using correlated particle pseudo-marginal algorithms," Computational Statistics & Data Analysis, Elsevier, vol. 157(C).
    8. Maud Delattre & Valentine Genon-Catalot & Catherine Larédo, 2018. "Approximate maximum likelihood estimation for stochastic differential equations with random effects in the drift and the diffusion," Metrika: International Journal for Theoretical and Applied Statistics, Springer, vol. 81(8), pages 953-983, November.
    9. Maud Delattre & Valentine Genon-Catalot & Adeline Samson, 2013. "Maximum Likelihood Estimation for Stochastic Differential Equations with Random Effects," Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics;Finnish Statistical Society;Norwegian Statistical Association;Swedish Statistical Association, vol. 40(2), pages 322-343, June.
    10. B. L. S. Prakasa Rao, 2021. "Nonparametric Estimation for Stochastic Differential Equations Driven by Mixed Fractional Brownian Motion with Random Effects," Sankhya A: The Indian Journal of Statistics, Springer;Indian Statistical Institute, vol. 83(2), pages 554-568, August.

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