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Cost-efficiency considerations in the choice of a microarray platform for time course experimental designs

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  • Lima Passos, Valéria
  • Tan, Frans E.S.
  • Berger, Martijn P.F.

Abstract

Customarily, the choice between one- or two-colour microarray platforms is based on their respective practical and technical merits, contingent on objectives and constraints of the study at stake. Statistical efficiency, if accounted for, plays a secondary role. A cost-efficiency comparison of the one- and two-colour designs for a 2x4 time course experiment was conducted. It is shown that differences in costs between the platforms' designs, once adjusted for statistical efficiency, are not always negligible. The extent of these differences is largely influenced by subjects and array prices as well as by biological and error variances in their relative magnitude. Circumstances are described, in which cost-efficiency considerations will have an added value in motivating the selection of a microarray platform at the design stage.

Suggested Citation

  • Lima Passos, Valéria & Tan, Frans E.S. & Berger, Martijn P.F., 2011. "Cost-efficiency considerations in the choice of a microarray platform for time course experimental designs," Computational Statistics & Data Analysis, Elsevier, vol. 55(1), pages 944-954, January.
    • Handle: RePEc:eee:csdana:v:55:y:2011:i:1:p:944-954
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    References listed on IDEAS

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    1. Tsai, Shin-Fu & Liao, Chen-Tuo & Chai, Feng-Shun, 2006. "Statistical designs for two-color microarray experiments involving technical replication," Computational Statistics & Data Analysis, Elsevier, vol. 51(3), pages 2078-2090, December.
    2. R. A. Bailey, 2007. "Designs for two‐colour microarray experiments," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 56(4), pages 365-394, August.
    3. Ernst Wit & Agostino Nobile & Raya Khanin, 2005. "Near‐optimal designs for dual channel microarray studies," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 54(5), pages 817-830, November.
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    Cited by:

    1. Jóźwiak, Katarzyna & Moerbeek, Mirjam, 2012. "Cost-effective designs for trials with discrete-time survival endpoints," Computational Statistics & Data Analysis, Elsevier, vol. 56(6), pages 2086-2096.
    2. Maryam Safarkhani & Mirjam Moerbeek, 2016. "D-optimal designs for a continuous predictor in longitudinal trials with discrete-time survival endpoints," Statistica Neerlandica, Netherlands Society for Statistics and Operations Research, vol. 70(2), pages 146-171, May.
    3. Safarkhani, Maryam & Moerbeek, Mirjam, 2014. "The influence of a covariate on optimal designs in longitudinal studies with discrete-time survival endpoints," Computational Statistics & Data Analysis, Elsevier, vol. 75(C), pages 217-226.

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