IDEAS home Printed from https://ideas.repec.org/a/eee/csdana/v55y2011i1p944-954.html
   My bibliography  Save this article

Cost-efficiency considerations in the choice of a microarray platform for time course experimental designs

Author

Listed:
  • Lima Passos, Valéria
  • Tan, Frans E.S.
  • Berger, Martijn P.F.

Abstract

Customarily, the choice between one- or two-colour microarray platforms is based on their respective practical and technical merits, contingent on objectives and constraints of the study at stake. Statistical efficiency, if accounted for, plays a secondary role. A cost-efficiency comparison of the one- and two-colour designs for a 2x4 time course experiment was conducted. It is shown that differences in costs between the platforms' designs, once adjusted for statistical efficiency, are not always negligible. The extent of these differences is largely influenced by subjects and array prices as well as by biological and error variances in their relative magnitude. Circumstances are described, in which cost-efficiency considerations will have an added value in motivating the selection of a microarray platform at the design stage.

Suggested Citation

  • Lima Passos, Valéria & Tan, Frans E.S. & Berger, Martijn P.F., 2011. "Cost-efficiency considerations in the choice of a microarray platform for time course experimental designs," Computational Statistics & Data Analysis, Elsevier, vol. 55(1), pages 944-954, January.
  • Handle: RePEc:eee:csdana:v:55:y:2011:i:1:p:944-954
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0167-9473(10)00241-0
    Download Restriction: Full text for ScienceDirect subscribers only.
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Tsai, Shin-Fu & Liao, Chen-Tuo & Chai, Feng-Shun, 2006. "Statistical designs for two-color microarray experiments involving technical replication," Computational Statistics & Data Analysis, Elsevier, vol. 51(3), pages 2078-2090, December.
    2. R. A. Bailey, 2007. "Designs for two‐colour microarray experiments," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 56(4), pages 365-394, August.
    3. Ernst Wit & Agostino Nobile & Raya Khanin, 2005. "Near‐optimal designs for dual channel microarray studies," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 54(5), pages 817-830, November.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Jóźwiak, Katarzyna & Moerbeek, Mirjam, 2012. "Cost-effective designs for trials with discrete-time survival endpoints," Computational Statistics & Data Analysis, Elsevier, vol. 56(6), pages 2086-2096.
    2. Maryam Safarkhani & Mirjam Moerbeek, 2016. "D-optimal designs for a continuous predictor in longitudinal trials with discrete-time survival endpoints," Statistica Neerlandica, Netherlands Society for Statistics and Operations Research, vol. 70(2), pages 146-171, May.
    3. Safarkhani, Maryam & Moerbeek, Mirjam, 2014. "The influence of a covariate on optimal designs in longitudinal studies with discrete-time survival endpoints," Computational Statistics & Data Analysis, Elsevier, vol. 75(C), pages 217-226.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Kerr Kathleen F., 2012. "Optimality Criteria for the Design of 2-Color Microarray Studies," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 11(1), pages 1-9, January.
    2. Godolphin, J.D. & Warren, H.R., 2014. "An efficient procedure for the avoidance of disconnected incomplete block designs," Computational Statistics & Data Analysis, Elsevier, vol. 71(C), pages 1134-1146.
    3. Ben M. Parker & Steven G. Gilmour & John Schormans, 2017. "Optimal design of experiments on connected units with application to social networks," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 66(3), pages 455-480, April.
    4. R. A. Bailey, 2007. "Designs for two‐colour microarray experiments," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 56(4), pages 365-394, August.
    5. Vasiliki Koutra & Steven G. Gilmour & Ben M. Parker, 2021. "Optimal block designs for experiments on networks," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 70(3), pages 596-618, June.
    6. Harman, Radoslav & Filová, Lenka, 2014. "Computing efficient exact designs of experiments using integer quadratic programming," Computational Statistics & Data Analysis, Elsevier, vol. 71(C), pages 1159-1167.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:csdana:v:55:y:2011:i:1:p:944-954. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.elsevier.com/locate/csda .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.