IDEAS home Printed from https://ideas.repec.org/a/eee/csdana/v194y2024ics0167947324000264.html
   My bibliography  Save this article

Sequential estimation for mixture of regression models for heterogeneous population

Author

Listed:
  • You, Na
  • Dai, Hongsheng
  • Wang, Xueqin
  • Yu, Qingyun

Abstract

Heterogeneity among patients commonly exists in clinical studies and leads to challenges in medical research. It is widely accepted that there exist various sub-types in the population and they are distinct from each other. The approach of identifying the sub-types and thus tailoring disease prevention and treatment is known as precision medicine. The mixture model is a classical statistical model to cluster the heterogeneous population into homogeneous sub-populations. However, for the highly heterogeneous population with multiple components, its parameter estimation and clustering results may be ambiguous due to the dependence of the EM algorithm on the initial values. For sub-typing purposes, the finite mixture of regression models with concomitant variables is considered and a novel statistical method is proposed to identify the main components with large proportions in the mixture sequentially. Compared to existing typical statistical inferences, the new method not only requires no pre-specification on the number of components for model fitting, but also provides more reliable parameter estimation and clustering results. Simulation studies demonstrated the superiority of the proposed method. Real data analysis on the drug response prediction illustrated its reliability in the parameter estimation and capability to identify the important subgroup.

Suggested Citation

  • You, Na & Dai, Hongsheng & Wang, Xueqin & Yu, Qingyun, 2024. "Sequential estimation for mixture of regression models for heterogeneous population," Computational Statistics & Data Analysis, Elsevier, vol. 194(C).
    • Handle: RePEc:eee:csdana:v:194:y:2024:i:c:s0167947324000264
    DOI: 10.1016/j.csda.2024.107942
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0167947324000264
    Download Restriction: Full text for ScienceDirect subscribers only.
    File URL: https://libkey.io/10.1016/j.csda.2024.107942?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Benaglia, Tatiana & Chauveau, Didier & Hunter, David R. & Young, Derek S., 2009. "mixtools: An R Package for Analyzing Mixture Models," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 32(i06).
    2. Sylvia. Richardson & Peter J. Green, 1997. "On Bayesian Analysis of Mixtures with an Unknown Number of Components (with discussion)," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 59(4), pages 731-792.
    3. Christina Curtis & Sohrab P. Shah & Suet-Feung Chin & Gulisa Turashvili & Oscar M. Rueda & Mark J. Dunning & Doug Speed & Andy G. Lynch & Shamith Samarajiwa & Yinyin Yuan & Stefan Gräf & Gavin Ha & Gh, 2012. "The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups," Nature, Nature, vol. 486(7403), pages 346-352, June.
    4. Wang, Shaoli & Yao, Weixin & Huang, Mian, 2014. "A note on the identifiability of nonparametric and semiparametric mixtures of GLMs," Statistics & Probability Letters, Elsevier, vol. 93(C), pages 41-45.
    5. Papastamoulis, Panagiotis, 2016. "label.switching: An R Package for Dealing with the Label Switching Problem in MCMC Outputs," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 69(c01).
    6. Grün, Bettina & Leisch, Friedrich, 2008. "FlexMix Version 2: Finite Mixtures with Concomitant Variables and Varying and Constant Parameters," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 28(i04).
    7. Matthew Stephens, 2000. "Dealing with label switching in mixture models," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 62(4), pages 795-809.
    8. Mian Huang & Weixin Yao, 2012. "Mixture of Regression Models With Varying Mixing Proportions: A Semiparametric Approach," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 107(498), pages 711-724, June.
    9. Lawrence Hubert & Phipps Arabie, 1985. "Comparing partitions," Journal of Classification, Springer;The Classification Society, vol. 2(1), pages 193-218, December.
    10. Mian Huang & Runze Li & Shaoli Wang, 2013. "Nonparametric Mixture of Regression Models," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 108(503), pages 929-941, September.
    11. Biernacki, Christophe & Celeux, Gilles & Govaert, Gerard, 2003. "Choosing starting values for the EM algorithm for getting the highest likelihood in multivariate Gaussian mixture models," Computational Statistics & Data Analysis, Elsevier, vol. 41(3-4), pages 561-575, January.
    12. Qianyun Li & Runmin Shi & Faming Liang, 2019. "Drug sensitivity prediction with high-dimensional mixture regression," PLOS ONE, Public Library of Science, vol. 14(2), pages 1-18, February.
    13. Jeffrey W. Miller & Matthew T. Harrison, 2018. "Mixture Models With a Prior on the Number of Components," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 113(521), pages 340-356, January.
    14. Mian Huang & Weixin Yao & Shaoli Wang & Yixin Chen, 2018. "Statistical Inference and Applications of Mixture of Varying Coefficient Models," Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics;Finnish Statistical Society;Norwegian Statistical Association;Swedish Statistical Association, vol. 45(3), pages 618-643, September.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Xue, Jiacheng & Yao, Weixin, 2022. "Machine Learning Embedded Semiparametric Mixtures of Regressions with Covariate-Varying Mixing Proportions," Econometrics and Statistics, Elsevier, vol. 22(C), pages 159-171.
    2. Derek S. Young & Xi Chen & Dilrukshi C. Hewage & Ricardo Nilo-Poyanco, 2019. "Finite mixture-of-gamma distributions: estimation, inference, and model-based clustering," Advances in Data Analysis and Classification, Springer;German Classification Society - Gesellschaft für Klassifikation (GfKl);Japanese Classification Society (JCS);Classification and Data Analysis Group of the Italian Statistical Society (CLADAG);International Federation of Classification Societies (IFCS), vol. 13(4), pages 1053-1082, December.
    3. Sijia Xiang & Weixin Yao, 2018. "Semiparametric mixtures of nonparametric regressions," Annals of the Institute of Statistical Mathematics, Springer;The Institute of Statistical Mathematics, vol. 70(1), pages 131-154, February.
    4. Marco Berrettini & Giuliano Galimberti & Saverio Ranciati, 2023. "Semiparametric finite mixture of regression models with Bayesian P-splines," Advances in Data Analysis and Classification, Springer;German Classification Society - Gesellschaft für Klassifikation (GfKl);Japanese Classification Society (JCS);Classification and Data Analysis Group of the Italian Statistical Society (CLADAG);International Federation of Classification Societies (IFCS), vol. 17(3), pages 745-775, September.
    5. Wan-Lun Wang & Yu-Chen Yang & Tsung-I Lin, 2024. "Extending finite mixtures of nonlinear mixed-effects models with covariate-dependent mixing weights," Advances in Data Analysis and Classification, Springer;German Classification Society - Gesellschaft für Klassifikation (GfKl);Japanese Classification Society (JCS);Classification and Data Analysis Group of the Italian Statistical Society (CLADAG);International Federation of Classification Societies (IFCS), vol. 18(2), pages 271-307, June.
    6. Sphiwe B. Skhosana & Salomon M. Millard & Frans H. J. Kanfer, 2023. "A Novel EM-Type Algorithm to Estimate Semi-Parametric Mixtures of Partially Linear Models," Mathematics, MDPI, vol. 11(5), pages 1-20, February.
    7. Im, Yunju & Tan, Aixin, 2021. "Bayesian subgroup analysis in regression using mixture models," Computational Statistics & Data Analysis, Elsevier, vol. 162(C).
    8. Sijia Xiang & Weixin Yao, 2020. "Semiparametric mixtures of regressions with single-index for model based clustering," Advances in Data Analysis and Classification, Springer;German Classification Society - Gesellschaft für Klassifikation (GfKl);Japanese Classification Society (JCS);Classification and Data Analysis Group of the Italian Statistical Society (CLADAG);International Federation of Classification Societies (IFCS), vol. 14(2), pages 261-292, June.
    9. Ye, Mao & Lu, Zhao-Hua & Li, Yimei & Song, Xinyuan, 2019. "Finite mixture of varying coefficient model: Estimation and component selection," Journal of Multivariate Analysis, Elsevier, vol. 171(C), pages 452-474.
    10. Yuan Fang & Dimitris Karlis & Sanjeena Subedi, 2022. "Infinite Mixtures of Multivariate Normal-Inverse Gaussian Distributions for Clustering of Skewed Data," Journal of Classification, Springer;The Classification Society, vol. 39(3), pages 510-552, November.
    11. Galimberti, Giuliano & Soffritti, Gabriele, 2014. "A multivariate linear regression analysis using finite mixtures of t distributions," Computational Statistics & Data Analysis, Elsevier, vol. 71(C), pages 138-150.
    12. Sylvia Frühwirth-Schnatter & Gertraud Malsiner-Walli, 2019. "From here to infinity: sparse finite versus Dirichlet process mixtures in model-based clustering," Advances in Data Analysis and Classification, Springer;German Classification Society - Gesellschaft für Klassifikation (GfKl);Japanese Classification Society (JCS);Classification and Data Analysis Group of the Italian Statistical Society (CLADAG);International Federation of Classification Societies (IFCS), vol. 13(1), pages 33-64, March.
    13. Hu, Hao & Wu, Yichao & Yao, Weixin, 2016. "Maximum likelihood estimation of the mixture of log-concave densities," Computational Statistics & Data Analysis, Elsevier, vol. 101(C), pages 137-147.
    14. Chun Yu & Weixin Yao & Guangren Yang, 2020. "A Selective Overview and Comparison of Robust Mixture Regression Estimators," International Statistical Review, International Statistical Institute, vol. 88(1), pages 176-202, April.
    15. Rodríguez, Carlos E. & Núñez-Antonio, Gabriel & Escarela, Gabriel, 2020. "A Bayesian mixture model for clustering circular data," Computational Statistics & Data Analysis, Elsevier, vol. 143(C).
    16. Naderi, Mehrdad & Mirfarah, Elham & Wang, Wan-Lun & Lin, Tsung-I, 2023. "Robust mixture regression modeling based on the normal mean-variance mixture distributions," Computational Statistics & Data Analysis, Elsevier, vol. 180(C).
    17. Salvatore D. Tomarchio & Luca Bagnato & Antonio Punzo, 2022. "Model-based clustering via new parsimonious mixtures of heavy-tailed distributions," AStA Advances in Statistical Analysis, Springer;German Statistical Society, vol. 106(2), pages 315-347, June.
    18. Riccardo Rastelli & Michael Fop, 2020. "A stochastic block model for interaction lengths," Advances in Data Analysis and Classification, Springer;German Classification Society - Gesellschaft für Klassifikation (GfKl);Japanese Classification Society (JCS);Classification and Data Analysis Group of the Italian Statistical Society (CLADAG);International Federation of Classification Societies (IFCS), vol. 14(2), pages 485-512, June.
    19. Roberto Mari & Salvatore Ingrassia & Antonio Punzo, 2023. "Local and Overall Deviance R-Squared Measures for Mixtures of Generalized Linear Models," Journal of Classification, Springer;The Classification Society, vol. 40(2), pages 233-266, July.
    20. Yanyuan Ma & Shaoli Wang & Lin Xu & Weixin Yao, 2021. "Semiparametric mixture regression with unspecified error distributions," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 30(2), pages 429-444, June.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:csdana:v:194:y:2024:i:c:s0167947324000264. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.elsevier.com/locate/csda .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.