IDEAS home Printed from https://ideas.repec.org/a/eee/csdana/v157y2021ics0167947320302528.html
   My bibliography  Save this article

Regression analysis of asynchronous longitudinal data with informative observation processes

Author

Listed:
  • Sun, Dayu
  • Zhao, Hui
  • Sun, Jianguo

Abstract

A great deal of literature has been established for regression analysis of longitudinal data but most of the existing methods assume that covariates can be observed completely or at the same observation times for the response variable, and the observation process is independent of the response variable completely or given covariates. As pointed out by many authors, in practice, one may face the situation where the response variable and covariates are observed intermittently at different time points, leading to sparse asynchronous longitudinal data, or the observation process may be related to the response variable even given covariates. It is apparent that sometimes both issues can occur in the same time and although some literature has been developed to address each of the two issues, it does not seem to exist an established approach that can deal with both together. To address this, in this paper, a flexible semiparametric transformation conditional model is presented and for estimation, a kernel-weighted estimating equation-based approach is proposed. The proposed estimators of regression parameters are shown to be consistent and asymptotically follow the normal distribution. For the assessment of the finite sample performance of the method, an extensive simulation study is carried out and suggests that it performs well for practical situations. The approach is applied to a prospective HIV study that motivated this investigation.

Suggested Citation

  • Sun, Dayu & Zhao, Hui & Sun, Jianguo, 2021. "Regression analysis of asynchronous longitudinal data with informative observation processes," Computational Statistics & Data Analysis, Elsevier, vol. 157(C).
    • Handle: RePEc:eee:csdana:v:157:y:2021:i:c:s0167947320302528
    DOI: 10.1016/j.csda.2020.107161
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0167947320302528
    Download Restriction: Full text for ScienceDirect subscribers only.
    File URL: https://libkey.io/10.1016/j.csda.2020.107161?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Lianqiang Qu & Liuquan Sun & Xinyuan Song, 2018. "A Joint Modeling Approach for Longitudinal Data with Informative Observation Times and a Terminal Event," Statistics in Biosciences, Springer;International Chinese Statistical Association, vol. 10(3), pages 609-633, December.
    2. Hongyuan Cao & Donglin Zeng & Jason P. Fine, 2015. "Regression analysis of sparse asynchronous longitudinal data," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 77(4), pages 755-776, September.
    3. Sun, Jianguo & Sun, Liuquan & Liu, Dandan, 2007. "Regression Analysis of Longitudinal Data in the Presence of Informative Observation and Censoring Times," Journal of the American Statistical Association, American Statistical Association, vol. 102, pages 1397-1406, December.
    4. Hongyuan Cao & Mathew M. Churpek & Donglin Zeng & Jason P. Fine, 2015. "Analysis of the Proportional Hazards Model With Sparse Longitudinal Covariates," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 110(511), pages 1187-1196, September.
    5. P. Diggle & M. G. Kenward, 1994. "Informative Drop‐Out in Longitudinal Data Analysis," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 43(1), pages 49-73, March.
    6. Haiqun Lin & Daniel O. Scharfstein & Robert A. Rosenheck, 2004. "Analysis of longitudinal data with irregular, outcome‐dependent follow‐up," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 66(3), pages 791-813, August.
    7. Xinyuan Song & Xiaoyun Mu & Liuquan Sun, 2012. "Regression Analysis of Longitudinal Data with Time-Dependent Covariates and Informative Observation Times," Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics;Finnish Statistical Society;Norwegian Statistical Association;Swedish Statistical Association, vol. 39(2), pages 248-258, June.
    8. Lin D Y & Wei L J & Ying Z, 2001. "Semiparametric Transformation Models for Point Processes," Journal of the American Statistical Association, American Statistical Association, vol. 96, pages 620-628, June.
    9. Sun, Jianguo & Park, Do-Hwan & Sun, Liuquan & Zhao, Xingqiu, 2005. "Semiparametric Regression Analysis of Longitudinal Data With Informative Observation Times," Journal of the American Statistical Association, American Statistical Association, vol. 100, pages 882-889, September.
    10. Zhao, Xingqiu & Tong, Xingwei & Sun, Jianguo, 2013. "Robust estimation for panel count data with informative observation times," Computational Statistics & Data Analysis, Elsevier, vol. 57(1), pages 33-40.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ting Li & Huichen Zhu & Tengfei Li & Hongtu Zhu, 2023. "Asynchronous functional linear regression models for longitudinal data in reproducing kernel Hilbert space," Biometrics, The International Biometric Society, vol. 79(3), pages 1880-1895, September.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Lianqiang Qu & Liuquan Sun & Xinyuan Song, 2018. "A Joint Modeling Approach for Longitudinal Data with Informative Observation Times and a Terminal Event," Statistics in Biosciences, Springer;International Chinese Statistical Association, vol. 10(3), pages 609-633, December.
    2. Qing Cai & Mei‐Cheng Wang & Kwun Chuen Gary Chan, 2017. "Joint modeling of longitudinal, recurrent events and failure time data for survivor's population," Biometrics, The International Biometric Society, vol. 73(4), pages 1150-1160, December.
    3. Na Cai & Wenbin Lu & Hao Helen Zhang, 2012. "Time-Varying Latent Effect Model for Longitudinal Data with Informative Observation Times," Biometrics, The International Biometric Society, vol. 68(4), pages 1093-1102, December.
    4. Li, Yang & Zhao, Hui & Sun, Jianguo & Kim, KyungMann, 2014. "Nonparametric tests for panel count data with unequal observation processes," Computational Statistics & Data Analysis, Elsevier, vol. 73(C), pages 103-111.
    5. Caleb Weaver & Luo Xiao & Wenbin Lu, 2023. "Functional data analysis for longitudinal data with informative observation times," Biometrics, The International Biometric Society, vol. 79(2), pages 722-733, June.
    6. Yu Liang & Wenbin Lu & Zhiliang Ying, 2009. "Joint Modeling and Analysis of Longitudinal Data with Informative Observation Times," Biometrics, The International Biometric Society, vol. 65(2), pages 377-384, June.
    7. Sun, Liuquan & Tong, Xingwei, 2009. "Analyzing longitudinal data with informative observation times under biased sampling," Statistics & Probability Letters, Elsevier, vol. 79(9), pages 1162-1168, May.
    8. Peter McCullagh, 2008. "Sampling bias and logistic models," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 70(4), pages 643-677, September.
    9. Zhou, Jie & Song, Xinyuan & Sun, Liuquan, 2020. "Continuous time hidden Markov model for longitudinal data," Journal of Multivariate Analysis, Elsevier, vol. 179(C).
    10. Zhuowei Sun & Hongyuan Cao & Li Chen, 2022. "Regression analysis of additive hazards model with sparse longitudinal covariates," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 28(2), pages 263-281, April.
    11. Deng, Shirong & Liu, Kin-yat & Zhao, Xingqiu, 2017. "Semiparametric regression analysis of multivariate longitudinal data with informative observation times," Computational Statistics & Data Analysis, Elsevier, vol. 107(C), pages 120-130.
    12. Hui Zhao & Yang Li & Jianguo Sun, 2013. "Semiparametric analysis of multivariate panel count data with dependent observation processes and a terminal event," Journal of Nonparametric Statistics, Taylor & Francis Journals, vol. 25(2), pages 379-394, June.
    13. Zhang, Haixiang & Zhao, Hui & Sun, Jianguo & Wang, Dehui & Kim, KyungMann, 2013. "Regression analysis of multivariate panel count data with an informative observation process," Journal of Multivariate Analysis, Elsevier, vol. 119(C), pages 71-80.
    14. Hangjin Jiang & Wen Su & Xingqiu Zhao, 2020. "Robust estimation for panel count data with informative observation times and censoring times," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 26(1), pages 65-84, January.
    15. Wang, Yijun & Wang, Weiwei & Zhao, Xiaobing, 2022. "Local logarithm partial likelihood estimation of panel count data model with an unknown link function," Computational Statistics & Data Analysis, Elsevier, vol. 166(C).
    16. David M. Murray & Jonathan L. Blitstein, 2003. "Methods To Reduce The Impact Of Intraclass Correlation In Group-Randomized Trials," Evaluation Review, , vol. 27(1), pages 79-103, February.
    17. Hongyuan Cao & Mathew M. Churpek & Donglin Zeng & Jason P. Fine, 2015. "Analysis of the Proportional Hazards Model With Sparse Longitudinal Covariates," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 110(511), pages 1187-1196, September.
    18. Patrick E. B. FitzGerald, 2002. "Extended Generalized Estimating Equations for Binary Familial Data with Incomplete Families," Biometrics, The International Biometric Society, vol. 58(4), pages 718-726, December.
    19. Pourahmadi, Mohsen & Daniels, Michael J. & Park, Trevor, 2007. "Simultaneous modelling of the Cholesky decomposition of several covariance matrices," Journal of Multivariate Analysis, Elsevier, vol. 98(3), pages 568-587, March.
    20. Lei Liu & Xuelin Huang & John O'Quigley, 2008. "Analysis of Longitudinal Data in the Presence of Informative Observational Times and a Dependent Terminal Event, with Application to Medical Cost Data," Biometrics, The International Biometric Society, vol. 64(3), pages 950-958, September.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:csdana:v:157:y:2021:i:c:s0167947320302528. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.elsevier.com/locate/csda .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.