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Equilibrium switching and mathematical properties of nonlinear interaction networks with concurrent antagonism and self-stimulation

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  • Rabajante, Jomar Fajardo
  • Talaue, Cherryl Ortega

Abstract

Concurrent decision-making model (CDM) of interaction networks with more than two antagonistic components represents various biological systems, such as gene interaction, species competition and mental cognition. The CDM model assumes sigmoid kinetics where every component stimulates itself but concurrently represses the others. Here we prove generic mathematical properties (e.g., location and stability of steady states) of n-dimensional CDM with either symmetric or asymmetric reciprocal antagonism between components. Significant modifications in parameter values serve as biological regulators for inducing steady state switching by driving a temporal state to escape an undesirable equilibrium. Increasing the maximal growth rate and decreasing the decay rate can expand the basin of attraction of a steady state that contains the desired dominant component. Perpetually adding an external stimulus could shut down multi-stability of the system which increases the robustness of the system against stochastic noise. We further show that asymmetric interaction forming a repressilator-type network generates oscillatory behavior.

Suggested Citation

  • Rabajante, Jomar Fajardo & Talaue, Cherryl Ortega, 2015. "Equilibrium switching and mathematical properties of nonlinear interaction networks with concurrent antagonism and self-stimulation," Chaos, Solitons & Fractals, Elsevier, vol. 73(C), pages 166-182.
    • Handle: RePEc:eee:chsofr:v:73:y:2015:i:c:p:166-182
    DOI: 10.1016/j.chaos.2015.01.018
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    1. Kyung H Kim & Herbert M Sauro, 2012. "Adjusting Phenotypes by Noise Control," PLOS Computational Biology, Public Library of Science, vol. 8(1), pages 1-14, January.
    2. Noah J Cowan & Erick J Chastain & Daril A Vilhena & James S Freudenberg & Carl T Bergstrom, 2012. "Nodal Dynamics, Not Degree Distributions, Determine the Structural Controllability of Complex Networks," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-5, June.
    3. Michael B. Elowitz & Stanislas Leibler, 2000. "A synthetic oscillatory network of transcriptional regulators," Nature, Nature, vol. 403(6767), pages 335-338, January.
    4. Kuznetsov, A. & Afraimovich, V., 2012. "Heteroclinic cycles in the repressilator model," Chaos, Solitons & Fractals, Elsevier, vol. 45(5), pages 660-665.
    5. Eric H. Davidson, 2010. "Emerging properties of animal gene regulatory networks," Nature, Nature, vol. 468(7326), pages 911-920, December.
    6. Todd S. Macfarlan & Wesley D. Gifford & Shawn Driscoll & Karen Lettieri & Helen M. Rowe & Dario Bonanomi & Amy Firth & Oded Singer & Didier Trono & Samuel L. Pfaff, 2012. "Embryonic stem cell potency fluctuates with endogenous retrovirus activity," Nature, Nature, vol. 487(7405), pages 57-63, July.
    7. Hannah H. Chang & Martin Hemberg & Mauricio Barahona & Donald E. Ingber & Sui Huang, 2008. "Transcriptome-wide noise controls lineage choice in mammalian progenitor cells," Nature, Nature, vol. 453(7194), pages 544-547, May.
    8. Shinya Yamanaka, 2009. "Elite and stochastic models for induced pluripotent stem cell generation," Nature, Nature, vol. 460(7251), pages 49-52, July.
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