IDEAS home Printed from https://ideas.repec.org/a/bpj/sagmbi/v7y2008i2n12.html
   My bibliography  Save this article

A Cross-Validation Study to Select a Classification Procedure for Clinical Diagnosis Based on Proteomic Mass Spectrometry

Author

Listed:
  • Valkenborg Dirk

    (Hasselt University, Center for Statistics)

  • Van Sanden Suzy

    (Hasselt University, Center for Statistics)

  • Lin Dan

    (Hasselt University, Center for Statistics)

  • Kasim Adetayo

    (Hasselt University, Center for Statistics)

  • Zhu Qi

    (Hasselt University, Center for Statistics)

  • Haldermans Philippe

    (Hasselt University, Center for Statistics)

  • Jansen Ivy

    (Hasselt University, Center for Statistics)

  • Shkedy Ziv

    (Hasselt University, Center for Statistics)

  • Burzykowski Tomasz

    (Hasselt University, Center for Statistics)

Abstract

We present an approach to construct a classification rule based on the mass spectrometry data provided by the organizers of the "Classification Competition on Clinical Mass Spectrometry Proteomic Diagnosis Data." Before constructing a classification rule, we attempted to pre-process the data and to select features of the spectra that were likely due to true biological signals (i.e., peptides/proteins). As a result, we selected a set of 92 features. To construct the classification rule, we considered eight methods for selecting a subset of the features, combined with seven classification methods. The performance of the resulting 56 combinations was evaluated by using a cross-validation procedure with 1000 re-sampled data sets. The best result, as indicated by the lowest overall misclassification rate, was obtained by using the whole set of 92 features as the input for a support-vector machine (SVM) with a linear kernel. This method was therefore used to construct the classification rule. For the training data set, the total error rate for the classification rule, as estimated by using leave-one-out cross-validation, was equal to 0.16, with the sensitivity and specificity equal to 0.87 and 0.82, respectively.

Suggested Citation

  • Valkenborg Dirk & Van Sanden Suzy & Lin Dan & Kasim Adetayo & Zhu Qi & Haldermans Philippe & Jansen Ivy & Shkedy Ziv & Burzykowski Tomasz, 2008. "A Cross-Validation Study to Select a Classification Procedure for Clinical Diagnosis Based on Proteomic Mass Spectrometry," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 7(2), pages 1-22, March.
  • Handle: RePEc:bpj:sagmbi:v:7:y:2008:i:2:n:12
    DOI: 10.2202/1544-6115.1363
    as

    Download full text from publisher

    File URL: https://doi.org/10.2202/1544-6115.1363
    Download Restriction: For access to full text, subscription to the journal or payment for the individual article is required.

    File URL: https://libkey.io/10.2202/1544-6115.1363?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Lee, Jae Won & Lee, Jung Bok & Park, Mira & Song, Seuck Heun, 2005. "An extensive comparison of recent classification tools applied to microarray data," Computational Statistics & Data Analysis, Elsevier, vol. 48(4), pages 869-885, April.
    2. Dudoit S. & Fridlyand J. & Speed T. P, 2002. "Comparison of Discrimination Methods for the Classification of Tumors Using Gene Expression Data," Journal of the American Statistical Association, American Statistical Association, vol. 97, pages 77-87, March.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Hand David J, 2008. "Breast Cancer Diagnosis from Proteomic Mass Spectrometry Data: A Comparative Evaluation," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 7(2), pages 1-23, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Alan R Dabney & John D Storey, 2007. "Optimality Driven Nearest Centroid Classification from Genomic Data," PLOS ONE, Public Library of Science, vol. 2(10), pages 1-7, October.
    2. Dong, Kai & Pang, Herbert & Tong, Tiejun & Genton, Marc G., 2016. "Shrinkage-based diagonal Hotelling’s tests for high-dimensional small sample size data," Journal of Multivariate Analysis, Elsevier, vol. 143(C), pages 127-142.
    3. Shieh Albert D & Hung Yeung Sam, 2009. "Detecting Outlier Samples in Microarray Data," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 8(1), pages 1-26, February.
    4. Lambert-Lacroix, Sophie & Peyre, Julie, 2006. "Local likelihood regression in generalized linear single-index models with applications to microarray data," Computational Statistics & Data Analysis, Elsevier, vol. 51(3), pages 2091-2113, December.
    5. Anne-Laure Boulesteix & Robert Hable & Sabine Lauer & Manuel J. A. Eugster, 2015. "A Statistical Framework for Hypothesis Testing in Real Data Comparison Studies," The American Statistician, Taylor & Francis Journals, vol. 69(3), pages 201-212, August.
    6. Yang, Tae Young, 2009. "Simple Bayesian binary framework for discovering significant genes and classifying cancer diagnosis," Computational Statistics & Data Analysis, Elsevier, vol. 53(5), pages 1743-1754, March.
    7. Scrucca, Luca, 2007. "Class prediction and gene selection for DNA microarrays using regularized sliced inverse regression," Computational Statistics & Data Analysis, Elsevier, vol. 52(1), pages 438-451, September.
    8. Conde David & Salvador Bonifacio & Rueda Cristina & Fernández Miguel A., 2013. "Performance and estimation of the true error rate of classification rules built with additional information. An application to a cancer trial," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 12(5), pages 583-602, October.
    9. Frénay, Benoît & Doquire, Gauthier & Verleysen, Michel, 2014. "Estimating mutual information for feature selection in the presence of label noise," Computational Statistics & Data Analysis, Elsevier, vol. 71(C), pages 832-848.
    10. Kubokawa, Tatsuya & Srivastava, Muni S., 2008. "Estimation of the precision matrix of a singular Wishart distribution and its application in high-dimensional data," Journal of Multivariate Analysis, Elsevier, vol. 99(9), pages 1906-1928, October.
    11. Hossain, Ahmed & Beyene, Joseph & Willan, Andrew R. & Hu, Pingzhao, 2009. "A flexible approximate likelihood ratio test for detecting differential expression in microarray data," Computational Statistics & Data Analysis, Elsevier, vol. 53(10), pages 3685-3695, August.
    12. Luca Scrucca, 2014. "Graphical tools for model-based mixture discriminant analysis," Advances in Data Analysis and Classification, Springer;German Classification Society - Gesellschaft für Klassifikation (GfKl);Japanese Classification Society (JCS);Classification and Data Analysis Group of the Italian Statistical Society (CLADAG);International Federation of Classification Societies (IFCS), vol. 8(2), pages 147-165, June.
    13. Bilin Zeng & Xuerong Meggie Wen & Lixing Zhu, 2017. "A link-free sparse group variable selection method for single-index model," Journal of Applied Statistics, Taylor & Francis Journals, vol. 44(13), pages 2388-2400, October.
    14. J. Burez & D. Van Den Poel, 2005. "CRM at a Pay-TV Company: Using Analytical Models to Reduce Customer Attrition by Targeted Marketing for Subscription Services," Working Papers of Faculty of Economics and Business Administration, Ghent University, Belgium 05/348, Ghent University, Faculty of Economics and Business Administration.
    15. Won, Joong-Ho & Lim, Johan & Yu, Donghyeon & Kim, Byung Soo & Kim, Kyunga, 2014. "Monotone false discovery rate," Statistics & Probability Letters, Elsevier, vol. 87(C), pages 86-93.
    16. Jan, Budczies & Kosztyla, Daniel & von Törne, Christian & Stenzinger, Albrecht & Darb-Esfahani, Silvia & Dietel, Manfred & Denkert, Carsten, 2014. "cancerclass: An R Package for Development and Validation of Diagnostic Tests from High-Dimensional Molecular Data," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 59(i01).
    17. Jianqing Fan & Yang Feng & Jiancheng Jiang & Xin Tong, 2016. "Feature Augmentation via Nonparametrics and Selection (FANS) in High-Dimensional Classification," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 111(513), pages 275-287, March.
    18. Márton Gosztonyi & Csákné Filep Judit, 2022. "Profiling (Non-)Nascent Entrepreneurs in Hungary Based on Machine Learning Approaches," Sustainability, MDPI, vol. 14(6), pages 1-20, March.
    19. Wang, Tao & Xu, Pei-Rong & Zhu, Li-Xing, 2012. "Non-convex penalized estimation in high-dimensional models with single-index structure," Journal of Multivariate Analysis, Elsevier, vol. 109(C), pages 221-235.
    20. Un Jung Lee & ShengLi Tzeng & Yu-Chuan Chen & James J Chen, 2017. "Development of Predictive Signatures for Treatment Selection in Precision Medicine," Biostatistics and Biometrics Open Access Journal, Juniper Publishers Inc., vol. 2(4), pages 83-88, August.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:bpj:sagmbi:v:7:y:2008:i:2:n:12. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Peter Golla (email available below). General contact details of provider: https://www.degruyter.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.