IDEAS home Printed from https://ideas.repec.org/a/bpj/fhecpo/v14y2011i3n6.html
   My bibliography  Save this article

Genome-Phenome Linkages in Human Population Surveys, with Special Emphasis on the Health and Retirement Survey

Author

Listed:
  • Singer Burton

    (Emerging Pathogens Institute, University of Florida, bhsinger@epi.ufl.edu)

Abstract

We review a diversity of genome-wide association studies (GWAS) with particular emphasis on precision in specifying phenotypes. This implies that examination of any specific phenotype involves considering the likely genetic contributions to it from the entire genome. We consider a variety of phenotypes specifiable with data from the Health and Retirement Survey (HRS). However, evidence from other large population studies is also incorporated as part of the process of developing and refining pathway representations from the genome thru a hierarchy of intermediate endpoints to behavioral, cognitive, and economic phenotypes. Any causal modeling focused on genome-phenotype connections must, of necessity, include consideration of intermediate endpoints (endophenotypes) as mediators of such associations. We also discuss metabolic and gene expression consequences of gene-environment interactions as a next research step beyond GWAS, not only for HRS but also for an integrated set of human population surveys that can provide much more statistical power than any one of them used alone. A variety of concrete examples based on physiological, psychological, sociological, and economic outcomes are carried along throughout our discussion.

Suggested Citation

  • Singer Burton, 2011. "Genome-Phenome Linkages in Human Population Surveys, with Special Emphasis on the Health and Retirement Survey," Forum for Health Economics & Policy, De Gruyter, vol. 14(2), pages 1-24, April.
    • Handle: RePEc:bpj:fhecpo:v:14:y:2011:i:3:n:6
    DOI: 10.2202/1558-9544.1261
    as

    Download full text from publisher

    File URL: https://doi.org/10.2202/1558-9544.1261
    Download Restriction: For access to full text, subscription to the journal or payment for the individual article is required.
    File URL: https://libkey.io/10.2202/1558-9544.1261?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. van der Loos, M.J.H.M. & Koellinger, Ph.D. & Groenen, P.J.F. & Thurik, A.R., 2010. "Genome-wide Association Studies and the Genetics of Entrepreneurship," ERIM Report Series Research in Management ERS-2010-004-ORG, Erasmus Research Institute of Management (ERIM), ERIM is the joint research institute of the Rotterdam School of Management, Erasmus University and the Erasmus School of Economics (ESE) at Erasmus University Rotterdam.
    2. André Stel & Martin Carree & Roy Thurik, 2005. "The Effect of Entrepreneurial Activity on National Economic Growth," Small Business Economics, Springer, vol. 24(3), pages 311-321, February.
    3. Philipp Koellinger & Matthijs Loos & Patrick Groenen & A. Thurik & Fernando Rivadeneira & Frank Rooij & André Uitterlinden & Albert Hofman, 2010. "Genome-wide association studies in economics and entrepreneurship research: promises and limitations," Small Business Economics, Springer, vol. 35(1), pages 1-18, July.
    4. Nicos Nicolaou & Scott Shane & Lynn Cherkas & Janice Hunkin & Tim D. Spector, 2008. "Is the Tendency to Engage in Entrepreneurship Genetic?," Management Science, INFORMS, vol. 54(1), pages 167-179, January.
    5. Martin Carree & A. R. Thurik (ed.), 2006. "Entrepreneurship and Economic Growth," Books, Edward Elgar Publishing, number 3673.
    6. Matthias Benz & Bruno S. Frey, 2008. "Being Independent is a Great Thing: Subjective Evaluations of Self‐Employment and Hierarchy," Economica, London School of Economics and Political Science, vol. 75(298), pages 362-383, May.
    7. Elaine Holmes & Ruey Leng Loo & Jeremiah Stamler & Magda Bictash & Ivan K. S. Yap & Queenie Chan & Tim Ebbels & Maria De Iorio & Ian J. Brown & Kirill A. Veselkov & Martha L. Daviglus & Hugo Kesteloot, 2008. "Human metabolic phenotype diversity and its association with diet and blood pressure," Nature, Nature, vol. 453(7193), pages 396-400, May.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Matthijs J H M van der Loos & Cornelius A Rietveld & Niina Eklund & Philipp D Koellinger & Fernando Rivadeneira & Gonçalo R Abecasis & Georgina A Ankra-Badu & Sebastian E Baumeister & Daniel J Benjami, 2013. "The Molecular Genetic Architecture of Self-Employment," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-15, April.
    2. Wim Naudé & José Ernesto Amorós & Oscar Cristi, 2011. "‘Surfeiting, The Appetite May Sicken’: Entrepreneurship and the Happiness of Nations," Working Papers 2011/07, Maastricht School of Management.
    3. Cornelius A. Rietveld & Eric A.W. Slob & A. Roy Thurik, 2021. "A decade of research on the genetics of entrepreneurship: a review and view ahead," Small Business Economics, Springer, vol. 57(3), pages 1303-1317, October.
    4. Philipp Koellinger & Matthijs Loos & Patrick Groenen & A. Thurik & Fernando Rivadeneira & Frank Rooij & André Uitterlinden & Albert Hofman, 2010. "Genome-wide association studies in economics and entrepreneurship research: promises and limitations," Small Business Economics, Springer, vol. 35(1), pages 1-18, July.
    5. Wim Naudé & José Amorós & Oscar Cristi, 2014. "“Surfeiting, the appetite may sicken”: entrepreneurship and happiness," Small Business Economics, Springer, vol. 42(3), pages 523-540, March.
    6. A. Roy Thurik & David B. Audretsch & Jörn H. Block & Andrew Burke & Martin A. Carree & Marcus Dejardin & Cornelius A. Rietveld & Mark Sanders & Ute Stephan & Johan Wiklund, 2024. "The impact of entrepreneurship research on other academic fields," Small Business Economics, Springer, vol. 62(2), pages 727-751, February.
    7. Matthijs Loos & Philipp Koellinger & Patrick Groenen & Cornelius Rietveld & Fernando Rivadeneira & Frank Rooij & André Uitterlinden & Albert Hofman & A. Thurik, 2011. "Candidate gene studies and the quest for the entrepreneurial gene," Small Business Economics, Springer, vol. 37(3), pages 269-275, October.
    8. Bhuiyan, Muhammad Faress & Ivlevs, Artjoms, 2019. "Micro-entrepreneurship and subjective well-being: Evidence from rural Bangladesh," Journal of Business Venturing, Elsevier, vol. 34(4), pages 625-645.
    9. Roy Thurik & Marcus Dejardin, 2012. "Entrepreneurship and Culture," Post-Print halshs-00943684, HAL.
    10. Matthew J. Lindquist & Joeri Sol & Mirjam Van Praag, 2015. "Why Do Entrepreneurial Parents Have Entrepreneurial Children?," Journal of Labor Economics, University of Chicago Press, vol. 33(2), pages 269-296.
    11. Renaud Bourlès & Anastasia Cozarenco, 2018. "Entrepreneurial motivation and business performance: evidence from a French Microfinance Institution," Small Business Economics, Springer, vol. 51(4), pages 943-963, December.
    12. Mirjam van Praag & Arjen van Witteloostuijn & Justin van der Sluis, 2009. "Returns for Entrepreneurs versus Employees: The Effect of Education and Personal Control on the Relative Performance of Entrepreneurs vis-a-vis Wage Employees," Tinbergen Institute Discussion Papers 09-111/3, Tinbergen Institute.
    13. Greene, Francis J. & Han, Liang & Martin, Sean & Zhang, Song & Wittert, Gary, 2014. "Testosterone is associated with self-employment among Australian men," Economics & Human Biology, Elsevier, vol. 13(C), pages 76-84.
    14. Benjamin A. Campbell, 2013. "Earnings Effects of Entrepreneurial Experience: Evidence from the Semiconductor Industry," Management Science, INFORMS, vol. 59(2), pages 286-304, February.
    15. Michael Wyrwich, 2015. "Entrepreneurship and the intergenerational transmission of values," Small Business Economics, Springer, vol. 45(1), pages 191-213, June.
    16. van der Loos, M.J.H.M. & Koellinger, Ph.D. & Groenen, P.J.F. & Thurik, A.R., 2010. "Genome-wide Association Studies and the Genetics of Entrepreneurship," ERIM Report Series Research in Management ERS-2010-004-ORG, Erasmus Research Institute of Management (ERIM), ERIM is the joint research institute of the Rotterdam School of Management, Erasmus University and the Erasmus School of Economics (ESE) at Erasmus University Rotterdam.
    17. Ana Venâncio & Inês Pinto, 2020. "Type of Entrepreneurial Activity and Sustainable Development Goals," Sustainability, MDPI, vol. 12(22), pages 1-25, November.
    18. van Praag, Mirjam C. & Raknerud, Arvid, 2017. "The Returns to Entrepreneurship: Evidence from Matched Person-Firm Data," IZA Discussion Papers 11018, Institute of Labor Economics (IZA).
    19. C. Praag & Peter Versloot, 2007. "What is the value of entrepreneurship? A review of recent research," Small Business Economics, Springer, vol. 29(4), pages 351-382, December.
    20. Michael Wyrwich, 2013. "In the name of my parents: Entrepreneurship and the intergenerational transmission of values," Jena Economics Research Papers 2013-031, Friedrich-Schiller-University Jena.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:bpj:fhecpo:v:14:y:2011:i:3:n:6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Peter Golla (email available below). General contact details of provider: https://www.degruyter.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.