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Joint Modeling of the Clinical Progression and of the Biomarkers' Dynamics Using a Mechanistic Model

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  • Jeremie Guedj
  • Rodolphe Thiébaut
  • Daniel Commenges

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  • Jeremie Guedj & Rodolphe Thiébaut & Daniel Commenges, 2011. "Joint Modeling of the Clinical Progression and of the Biomarkers' Dynamics Using a Mechanistic Model," Biometrics, The International Biometric Society, vol. 67(1), pages 59-66, March.
    • Handle: RePEc:bla:biomet:v:67:y:2011:i:1:p:59-66
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    File URL: http://hdl.handle.net/10.1111/j.1541-0420.2010.01418.x
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    References listed on IDEAS

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    1. Daniel Commenges & Anne Gégout‐Petit, 2009. "A general dynamical statistical model with causal interpretation," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 71(3), pages 719-736, June.
    2. Samson, Adeline & Lavielle, Marc & Mentre, France, 2006. "Extension of the SAEM algorithm to left-censored data in nonlinear mixed-effects model: Application to HIV dynamics model," Computational Statistics & Data Analysis, Elsevier, vol. 51(3), pages 1562-1574, December.
    3. David D. Ho & Avidan U. Neumann & Alan S. Perelson & Wen Chen & John M. Leonard & Martin Markowitz, 1995. "Rapid Turnover of Plasma Virions and CD4 Lymphocytes in HIV-1 Infection," Working Papers 95-01-002, Santa Fe Institute.
    4. Yangxin Huang & Dacheng Liu & Hulin Wu, 2006. "Hierarchical Bayesian Methods for Estimation of Parameters in a Longitudinal HIV Dynamic System," Biometrics, The International Biometric Society, vol. 62(2), pages 413-423, June.
    5. J. Guedj & R. Thiébaut & D. Commenges, 2007. "Maximum Likelihood Estimation in Dynamical Models of HIV," Biometrics, The International Biometric Society, vol. 63(4), pages 1198-1206, December.
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    Cited by:

    1. Solène Desmée & France Mentré & Christine Veyrat-Follet & Bernard Sébastien & Jérémie Guedj, 2017. "Using the SAEM algorithm for mechanistic joint models characterizing the relationship between nonlinear PSA kinetics and survival in prostate cancer patients," Biometrics, The International Biometric Society, vol. 73(1), pages 305-312, March.

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