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Using Bioinformatics to predict potential targets of Microrna-144 in osteoarthritis

Author

Listed:
  • Ho Thi Bich Phuong

    (Ho Chi Minh City Open University, Vietnam)

  • Vien Ngoc Thach

    (Ho Chi Minh City Open University, Vietnam)

  • Luong Hoang Ngan

    (Ho Chi Minh City Open University, Vietnam)

  • Le Thi Truc Linh

    (Ho Chi Minh City Open University, Vietnam)

Abstract

MicroRNAs are short endogenous non-coding RNA molecules, typically 19-25 nucleotides in length, which negatively regulate gene expression through binding to 3’UTR of target mRNAs, leading to repression of protein translation or target mRNA degradation. MicroRNA-144 (miR-144) was found as an abnormal expression in various diseases, including osteoarthritis (OA). We have identified increased microRNA-144 expression in early phase and end stage of OA. However, the molecular mechanism of this increase has not been yet to be determined yet. Using bioinformatics tools, we found more than 4,000 mRNAs that are predicted to be potential direct targets of miR-144, including mRNAs involved in the critical signaling pathways in OA e.g. TGFβ/Smad2/3 and WNT/β-catenin. Results from this research provide information for future ex periments to validate miR-144 potential targets.

Suggested Citation

  • Ho Thi Bich Phuong & Vien Ngoc Thach & Luong Hoang Ngan & Le Thi Truc Linh, 2018. "Using Bioinformatics to predict potential targets of Microrna-144 in osteoarthritis," HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE - ENGINEERING AND TECHNOLOGY, HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE, HO CHI MINH CITY OPEN UNIVERSITY, vol. 8(1), pages 43-52.
    • Handle: RePEc:bjw:techen:v:8:y:2018:i:1:p:43-52
    DOI: 10.46223/HCMCOUJS.tech.en.8.1.335.2018
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    1. Joacim Elmén & Morten Lindow & Sylvia Schütz & Matthew Lawrence & Andreas Petri & Susanna Obad & Marie Lindholm & Maj Hedtjärn & Henrik Frydenlund Hansen & Urs Berger & Steven Gullans & Phil Kearney &, 2008. "LNA-mediated microRNA silencing in non-human primates," Nature, Nature, vol. 452(7189), pages 896-899, April.
    2. Jan Krützfeldt & Nikolaus Rajewsky & Ravi Braich & Kallanthottathil G. Rajeev & Thomas Tuschl & Muthiah Manoharan & Markus Stoffel, 2005. "Silencing of microRNAs in vivo with ‘antagomirs’," Nature, Nature, vol. 438(7068), pages 685-689, December.
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