IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v452y2008i7189d10.1038_nature06783.html
   My bibliography  Save this article

LNA-mediated microRNA silencing in non-human primates

Author

Listed:
  • Joacim Elmén

    (Santaris Pharma, Bøge Allé 3, DK-2970 Hørsholm, Denmark)

  • Morten Lindow

    (Santaris Pharma, Bøge Allé 3, DK-2970 Hørsholm, Denmark)

  • Sylvia Schütz

    (299 Campus Drive, Stanford University School of Medicine, Stanford, California 94305, USA)

  • Matthew Lawrence

    (RxGen Inc, 100 Deepwood Drive, Hamden, Connecticut 06517, USA)

  • Andreas Petri

    (Santaris Pharma, Bøge Allé 3, DK-2970 Hørsholm, Denmark)

  • Susanna Obad

    (Santaris Pharma, Bøge Allé 3, DK-2970 Hørsholm, Denmark)

  • Marie Lindholm

    (Santaris Pharma, Bøge Allé 3, DK-2970 Hørsholm, Denmark)

  • Maj Hedtjärn

    (Santaris Pharma, Bøge Allé 3, DK-2970 Hørsholm, Denmark)

  • Henrik Frydenlund Hansen

    (Santaris Pharma, Bøge Allé 3, DK-2970 Hørsholm, Denmark)

  • Urs Berger

    (UB-in situ, PO Box 463, Natick, Massachusetts 01760, USA)

  • Steven Gullans

    (RxGen Inc, 100 Deepwood Drive, Hamden, Connecticut 06517, USA)

  • Phil Kearney

    (Santaris Pharma, Bøge Allé 3, DK-2970 Hørsholm, Denmark)

  • Peter Sarnow

    (299 Campus Drive, Stanford University School of Medicine, Stanford, California 94305, USA)

  • Ellen Marie Straarup

    (Santaris Pharma, Bøge Allé 3, DK-2970 Hørsholm, Denmark)

  • Sakari Kauppinen

    (Santaris Pharma, Bøge Allé 3, DK-2970 Hørsholm, Denmark
    Wilhelm Johannsen Centre for Functional Genome Research, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark)

Abstract

'Therapeutic' microRNA The realization that microRNAs play a central role in gene regulation in both normal development and disease, such as cancer, cardiac disease and metabolic disorders, suggests that they might be viable targets for therapeutic intervention. Now, for the first time, efficient, long-lasting and reversible microRNA silencing has been achieved in non-human primates. African green monkeys received intraperitoneal injections of a short modified DNA sequence that binds to and blocks the function of miR-122, a microRNA that regulates genes that influence cholesterol levels. Dose-dependent lowering of blood cholesterol followed, with no signs of toxicity. It is still a giant leap to therapeutic applications and, as microRNAs can act on many genes, toxicity risks are considerable.

Suggested Citation

  • Joacim Elmén & Morten Lindow & Sylvia Schütz & Matthew Lawrence & Andreas Petri & Susanna Obad & Marie Lindholm & Maj Hedtjärn & Henrik Frydenlund Hansen & Urs Berger & Steven Gullans & Phil Kearney &, 2008. "LNA-mediated microRNA silencing in non-human primates," Nature, Nature, vol. 452(7189), pages 896-899, April.
    • Handle: RePEc:nat:nature:v:452:y:2008:i:7189:d:10.1038_nature06783
    DOI: 10.1038/nature06783
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature06783
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature06783?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ho Thi Bich Phuong & Vien Ngoc Thach & Luong Hoang Ngan & Le Thi Truc Linh, 2018. "Using Bioinformatics to predict potential targets of Microrna-144 in osteoarthritis," HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE - ENGINEERING AND TECHNOLOGY, HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE, HO CHI MINH CITY OPEN UNIVERSITY, vol. 8(1), pages 43-52.
    2. Mei Liu & Jibing Liu & Liming Wang & Huiyong Wu & Changchun Zhou & Hongxia Zhu & Ningzhi Xu & Yinfa Xie, 2014. "Association of Serum MicroRNA Expression in Hepatocellular Carcinomas Treated with Transarterial Chemoembolization and Patient Survival," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-8, October.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:452:y:2008:i:7189:d:10.1038_nature06783. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.