IDEAS home Printed from https://ideas.repec.org/a/arp/rjbarp/2017p1-9.html
   My bibliography  Save this article

The Future is Still Ahead: Methodologies for Discovering New Antimicrobials within the World Biodiversity

Author

Listed:
  • Nunes E. L. C.

    (Universidade Federal Fluminense, LABiEMol, PPBI, Outeiro de São João Baptista, CEP 24020-141, Niterói, RJ, Brazil)

  • Novais J. S.

    (Universidade Federal Fluminense, LABiEMol, PPBI, Outeiro de São João Baptista, CEP 24020-141, Niterói, RJ, Brazil)

  • Silva A. C. J. A.

    (Universidade Federal Fluminense, LABiEMol, PPBI, Outeiro de São João Baptista, CEP 24020-141, Niterói, RJ, Brazil)

  • Guerra L. R.

    (Universidade Federal Fluminense, LABiEMol, PPBI, Outeiro de São João Baptista, CEP 24020-141, Niterói, RJ, Brazil)

  • Castro H. C.

    (Universidade Federal Fluminense, LABiEMol, PPBI, Outeiro de São João Baptista, CEP 24020-141, Niterói, RJ, Brazil)

Abstract

The use of antimicrobials is essential to treat infectious diseases worldwide. However, the abusive and/or inappropriate use of these molecules have contributed to the development of resistant bacterial strains, restricting the current treatment options. This resistance phenomenon boosts the need for searching new antibacterial molecules to treat human and animal populations. Currently places and countries with high biodiversity such as Brazilian Amazon forest and Brazil, which is member of a group with 17 mega diverse countries, are pointed as promising environments for identifying new antibiotics and still have to be explored. However this biotechnological potential is far from getting to the population as these countries neither open their biodiversity to others nor efficiently explore it. In this work we aim to briefly review some of the simplest in vitro and in silico laboratory methodologies to identify new antimicrobial prototypes to stimulate these countries to explore their own biodiversity as well as to other countries that are interested on researching natural products and new molecules. This work intend to contribute to unveil this unexplored biodiversity world as well as to improve the development of new therapeutic options to fight against bacterial infections worldwide.Â

Suggested Citation

  • Nunes E. L. C. & Novais J. S. & Silva A. C. J. A. & Guerra L. R. & Castro H. C., 2017. "The Future is Still Ahead: Methodologies for Discovering New Antimicrobials within the World Biodiversity," Journal of Biotechnology Research, Academic Research Publishing Group, vol. 3(1), pages 1-9, 01-2017.
  • Handle: RePEc:arp:rjbarp:2017:p:1-9
    DOI: arpgweb.com/?ic=journal&journal=16&info=aims
    as

    Download full text from publisher

    File URL: http://www.arpgweb.com/pdf-files/jbr3(1)1-9.pdf
    Download Restriction: no

    File URL: http://www.arpgweb.com/?ic=journal&journal=16&month=01-2017&issue=1&volume=3
    Download Restriction: no

    File URL: https://libkey.io/arpgweb.com/?ic=journal&journal=16&info=aims?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Ian B. Seiple & Ziyang Zhang & Pavol Jakubec & Audrey Langlois-Mercier & Peter M. Wright & Daniel T. Hog & Kazuo Yabu & Senkara Rao Allu & Takehiro Fukuzaki & Peter N. Carlsen & Yoshiaki Kitamura & Xi, 2016. "A platform for the discovery of new macrolide antibiotics," Nature, Nature, vol. 533(7603), pages 338-345, May.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Christopher J. Barden & Fan Wu & J. Pedro Fernandez-Murray & Erhu Lu & Shengguo Sun & Marcia M. Taylor & Annette L. Rushton & Jason Williams & Mahtab Tavasoli & Autumn Meek & Alla Siva Reddy & Lisa M., 2024. "Computer-aided drug design to generate a unique antibiotic family," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    2. Chih-Wei Chen & Nadja Leimer & Egor A. Syroegin & Clémence Dunand & Zackery P. Bulman & Kim Lewis & Yury S. Polikanov & Maxim S. Svetlov, 2023. "Structural insights into the mechanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. Cristina Herencias & Laura Álvaro-Llorente & Paula Ramiro-Martínez & Ariadna Fernández-Calvet & Ada Muñoz-Cazalla & Javier DelaFuente & Fabrice E. Graf & Laura Jaraba-Soto & Juan Antonio Castillo-Polo, 2024. "β-lactamase expression induces collateral sensitivity in Escherichia coli," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    4. Xiaokang Lv & Fen Su & Hongyan Long & Fengfei Lu & Yukun Zeng & Minghong Liao & Fengrui Che & Xingxing Wu & Yonggui Robin Chi, 2024. "Carbene organic catalytic planar enantioselective macrolactonization," Nature Communications, Nature, vol. 15(1), pages 1-7, December.
    5. Darryl M. Wilson & Daniel J. Driedger & Dennis Y. Liu & Sandra Keerthisinghe & Adrian Hermann & Christoph Bieniossek & Roger G. Linington & Robert A. Britton, 2024. "Targeted sampling of natural product space to identify bioactive natural product-like polyketide macrolides," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    6. Sebastián Serna-Loaiza & Angela Miltner & Martin Miltner & Anton Friedl, 2019. "A Review on the Feedstocks for the Sustainable Production of Bioactive Compounds in Biorefineries," Sustainability, MDPI, vol. 11(23), pages 1-24, November.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:arp:rjbarp:2017:p:1-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Managing Editor (email available below). General contact details of provider: http://arpgweb.com/index.php?ic=journal&journal=16&info=aims .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.