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Erythrocyte Acetylcholinesterase is a Signaling Receptor

Author

Listed:
  • Carlota Saldanha
  • Ana Silva Herdade

    (Institute of Biochemistry, Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Portugal)

Abstract

The acetylcholinesterase (AChE), is an enzyme located in the erythrocyte membrane that motivate continually questions, about its physiological function. The aim of this mini review is highlight the receptor behavior of AChE in human red blood cells for chemical signals associated with nitric oxide mobilization and efflux from erythrocytes. Data from the experimental models used are presented. Consequently, key participative proteins in the steps of the signal transduction pathways, in dependence of AChE receptor, are suggested to be further considered as potential therapeutic targets.

Suggested Citation

  • Carlota Saldanha & Ana Silva Herdade, 2018. "Erythrocyte Acetylcholinesterase is a Signaling Receptor," Novel Approaches in Drug Designing & Development, Juniper Publishers Inc., vol. 3(4), pages 77-80, January.
    • Handle: RePEc:adp:jnapdd:v:3:y:2018:i:4:p:77-80
    DOI: 10.19080/NAPDD.2018.03.555617
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    References listed on IDEAS

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    1. Carlota Saldanha & Ana Silva Herdade, 2017. "Erythrocyte as a Therapeutic Target," Novel Approaches in Drug Designing & Development, Juniper Publishers Inc., vol. 2(3), pages 64-66, August.
    2. Kevin J. Tracey, 2002. "The inflammatory reflex," Nature, Nature, vol. 420(6917), pages 853-859, December.
    3. Lyudmila V. Borovikova & Svetlana Ivanova & Minghuang Zhang & Huan Yang & Galina I. Botchkina & Linda R. Watkins & Haichao Wang & Naji Abumrad & John W. Eaton & Kevin J. Tracey, 2000. "Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin," Nature, Nature, vol. 405(6785), pages 458-462, May.
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    Cited by:

    1. Carlota Saldanha, 2020. "Therapeutic Approach for Covid-19 Patients," Novel Approaches in Drug Designing & Development, Juniper Publishers Inc., vol. 5(3), pages 55-57, September.

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