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TG could Modulate FPN1 in MES 23.5 Cells by Hepcidin

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  • Li Qi jun

Abstract

Objective To observe the effects of thapsigargin (TG) on ferroportin1 (FPN1) in MES23.5 dopaminergic cell. Methods MES23.5 cells were treated with TG (0.1 μM or 1 μM) for 24h. the mRNA levels of hepcidin were measured using real-time PCR; The protein levels of CHOP, XBP-1s and FPN1 were measured using western blots. Results CHOP and XBP-1s expression was significantly higher in the TG-treated group than that in the control group; hepcidin mRNA levels in TG-treated group were up-regulated, this increase was to a larger extent in the 1 μM TG group when compare with the 0.1 μM TG group; however, FPN1 expression was significantly lower in the TG-treated group, this decrease was to a larger extent in the 1 μM TG group when compare with the 0.1 μM TG group. Conclusion TG could modulate FPN1 in MES23.5 cells by hepcidin.

Suggested Citation

  • Li Qi jun, 2018. "TG could Modulate FPN1 in MES 23.5 Cells by Hepcidin," International Journal of Sciences, Office ijSciences, vol. 7(09), pages 52-55, September.
    • Handle: RePEc:adm:journl:v:7:y:2018:i:9:p:52-55
    DOI: 10.18483/ijSci.1805
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    1. Miao Wang & Randal J. Kaufman, 2016. "Protein misfolding in the endoplasmic reticulum as a conduit to human disease," Nature, Nature, vol. 529(7586), pages 326-335, January.
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