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Psychosocial functioning, quality of life and clinical correlates of ă comorbid alcohol and drug dependence syndromes in people with ă schizophrenia across Europe

Author

Listed:
  • Giuseppe Carra
  • Sonia Johnson
  • Cristina Crocamo
  • Matthias C. Angermeyer

    (Leipzig University / Universität Leipzig)

  • Traolach Brugha

    (Leicester NIHR Biomedical Research Unit in Cardiovascular Disease - University of Leicester)

  • Jean-Michel Azorin

    (Fondation FondaMental [Créteil], Pôle de Psychiatrie - AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) - Hôpitaux Sud - Hôpital Sainte-Marguerite [CHU - APHM] - CHU Marseille)

  • Mondher Toumi

    (Pharmaco-Epidémiologie - Université Bordeaux Segalen - Bordeaux 2 - INSERM - Institut National de la Santé et de la Recherche Médicale)

  • Paul E. Bebbington

Abstract

Little is known about the correlates of comorbid drug and alcohol ă dependence in people with schizophrenia outside the USA. We tested ă hypotheses that dependence on alcohol/drugs would be associated with ă more severe symptoms, and poorer psychosocial functioning and quality of ă life. The EuroSC Cohort study (N=1204), based in France, Germany and the ă UK, used semi-structured clinical interviews for diagnoses, and ă standardized tools to assess correlates. We used mixed models to compare ă outcomes between past-year comorbid dependence on alcohol/drugs, ă controlling for covariates and modelling both subject and country-level ă effects. Participants dependent on alcohol or drugs had fewer negative ă symptoms on PANSS than their non-dependent counterparts. However, those ă dependent on alcohol scored higher on PANSS general psychopathology than ă those who were not, or dependent only on drugs. People with ă schizophrenia dependent on drugs had poorer quality of life, more ă extrapyramidal side effects, and scored worse on Global Assessment of ă Functioning (GAF) than those without dependence. People with alcohol ă dependence reported more reasons for non-compliance with medication, and ă poorer functioning on GAF, though not on Global Assessment of Relational ă Functioning. In people with schizophrenia, comorbid dependence on ă alcohol or drugs is associated with impaired clinical and psycho social ă adjustment, and poorer quality of life. (C) 2016 Elsevier Ireland Ltd. ă All rights reserved.

Suggested Citation

  • Giuseppe Carra & Sonia Johnson & Cristina Crocamo & Matthias C. Angermeyer & Traolach Brugha & Jean-Michel Azorin & Mondher Toumi & Paul E. Bebbington, 2016. "Psychosocial functioning, quality of life and clinical correlates of ă comorbid alcohol and drug dependence syndromes in people with ă schizophrenia across Europe," Post-Print hal-01482524, HAL.
    • Handle: RePEc:hal:journl:hal-01482524
    DOI: 10.1016/j.psychres.2016.03.038
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    Cited by:

    1. Giuseppe Carrà & Francesco Bartoli & Ilaria Riboldi & Giulia Trotta & Cristina Crocamo, 2018. "Poverty matters: Cannabis use among people with serious mental illness: Findings from the United States survey on drug use and health, 2015," International Journal of Social Psychiatry, , vol. 64(7), pages 656-659, November.

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