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Genetic susceptibility to depression and the role of partnership status

Author

Listed:
  • Maria Gueltzow

    (Max Planck Institute for Demographic Research, Rostock, Germany)

  • Hannu Lahtinen
  • Maarten J. Bijlsma

    (Max Planck Institute for Demographic Research, Rostock, Germany)

  • Mikko Myrskylä

    (Max Planck Institute for Demographic Research, Rostock, Germany)

  • Pekka Martikainen

    (Max Planck Institute for Demographic Research, Rostock, Germany)

Abstract

This study explored the interplay between genetic predisposition, partnership status and depression by examining the association of a polygenic risk score (PGS) for depression with time to antidepressant purchasing and the moderating role of partnership status. We analysed data from 30,192 Finnish individuals with an accelerated failure time model. While the cumulative hazard of antidepressant purchasing varied across PGS and partnership status – with the highest cumulative hazard in the widowed group, followed by divorced, single, married and cohabiting – we found no evidence for an interaction between PGS and partnership status. Results were robust to different model specifications, gender stratification, choice of PGS, and endogenous selection. Although antidepressant purchasing correlated with both PGS and partnership status, we found no evidence that partnership status could partially offset or amplify the association between the PGS for depression and depression incidence.

Suggested Citation

  • Maria Gueltzow & Hannu Lahtinen & Maarten J. Bijlsma & Mikko Myrskylä & Pekka Martikainen, 2023. "Genetic susceptibility to depression and the role of partnership status," MPIDR Working Papers WP-2023-049, Max Planck Institute for Demographic Research, Rostock, Germany.
    • Handle: RePEc:dem:wpaper:wp-2023-049
    DOI: 10.4054/MPIDR-WP-2023-049
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    References listed on IDEAS

    as
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    More about this item

    Keywords

    Finland; genetics; marital status; mental health;
    All these keywords.

    JEL classification:

    • J1 - Labor and Demographic Economics - - Demographic Economics
    • Z0 - Other Special Topics - - General

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