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Counting Clinical Trials: New Evidence on Pharmaceutical Sector Productivity

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  • Maya M. Durvasula
  • Sabri Eyuboglu
  • David M. Ritzwoller

Abstract

We develop a method for assigning high-quality labels to unstructured text. This method is based on fine-tuning an efficient, open-source language model with data extracted from a large, proprietary language model. We apply this method to construct a census of published clinical trials. With these data, we revisit a literature that contends that pharmaceutical sector productivity is declining. Central to this conclusion are measurements of substantial increases in the quantity of clinical trials over time, unmatched by trends in measures of output. In our data, the quantity, quality, and composition of clinical trials are stable since 2010. We show that previous measurements are an artifact of biases introduced by shifts in the composition of other forms of research.

Suggested Citation

  • Maya M. Durvasula & Sabri Eyuboglu & David M. Ritzwoller, 2024. "Counting Clinical Trials: New Evidence on Pharmaceutical Sector Productivity," Papers 2405.08030, arXiv.org, revised Jan 2025.
    • Handle: RePEc:arx:papers:2405.08030
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    1. Benjamin F. Jones, 2009. "The Burden of Knowledge and the "Death of the Renaissance Man": Is Innovation Getting Harder?," The Review of Economic Studies, Review of Economic Studies Ltd, vol. 76(1), pages 283-317.
    2. Nicholas Bloom & Charles I. Jones & John Van Reenen & Michael Webb, 2020. "Are Ideas Getting Harder to Find?," American Economic Review, American Economic Association, vol. 110(4), pages 1104-1144, April.
    3. Kenneth F Schulz & Douglas G Altman & David Moher & for the CONSORT Group, 2010. "CONSORT 2010 Statement: Updated Guidelines for Reporting Parallel Group Randomised Trials," PLOS Medicine, Public Library of Science, vol. 7(3), pages 1-7, March.
    4. Chad Syverson, 2017. "Challenges to Mismeasurement Explanations for the US Productivity Slowdown," Journal of Economic Perspectives, American Economic Association, vol. 31(2), pages 165-186, Spring.
    5. Daron Acemoglu & Simon Johnson, 2007. "Disease and Development: The Effect of Life Expectancy on Economic Growth," Journal of Political Economy, University of Chicago Press, vol. 115(6), pages 925-985, December.
    6. Aghion, Philippe & Howitt, Peter, 1992. "A Model of Growth through Creative Destruction," Econometrica, Econometric Society, vol. 60(2), pages 323-351, March.
    7. Josh Angrist & Pierre Azoulay & Glenn Ellison & Ryan Hill & Susan Feng Lu, 2020. "Inside Job or Deep Impact? Extramural Citations and the Influence of Economic Scholarship," Journal of Economic Literature, American Economic Association, vol. 58(1), pages 3-52, March.
    8. Bryan Kelly & Dimitris Papanikolaou & Amit Seru & Matt Taddy, 2021. "Measuring Technological Innovation over the Long Run," American Economic Review: Insights, American Economic Association, vol. 3(3), pages 303-320, September.
    9. DiMasi, Joseph A. & Grabowski, Henry G. & Hansen, Ronald W., 2016. "Innovation in the pharmaceutical industry: New estimates of R&D costs," Journal of Health Economics, Elsevier, vol. 47(C), pages 20-33.
    10. Alwyn Young, 1998. "Growth without Scale Effects," Journal of Political Economy, University of Chicago Press, vol. 106(1), pages 41-63, February.
    11. Douglas Almond & Joseph J. Doyle & Amanda E. Kowalski & Heidi Williams, 2010. "Estimating Marginal Returns to Medical Care: Evidence from At-risk Newborns," The Quarterly Journal of Economics, President and Fellows of Harvard College, vol. 125(2), pages 591-634.
    12. Philippe Aghion & Ufuk Akcigit & Antonin Bergeaud & Richard Blundell & David Hemous, 2019. "Innovation and Top Income Inequality," The Review of Economic Studies, Review of Economic Studies Ltd, vol. 86(1), pages 1-45.
    13. Michael Park & Erin Leahey & Russell J. Funk, 2023. "Papers and patents are becoming less disruptive over time," Nature, Nature, vol. 613(7942), pages 138-144, January.
    14. Jones, Charles I, 1995. "R&D-Based Models of Economic Growth," Journal of Political Economy, University of Chicago Press, vol. 103(4), pages 759-784, August.
    15. Peretto, Pietro F, 1998. "Technological Change and Population Growth," Journal of Economic Growth, Springer, vol. 3(4), pages 283-311, December.
    16. Lisa Larrimore Ouellette & Bhaven N. Sampat, 2024. "The Feasibility of Using Bayh-Dole March-In Rights to Lower Drug Prices: An Update," NBER Working Papers 32217, National Bureau of Economic Research, Inc.
    17. Daron Acemoglu & David Autor & Christina Patterson, 2024. "Bottlenecks: Sectoral Imbalances and the US Productivity Slowdown," NBER Macroeconomics Annual, University of Chicago Press, vol. 38(1), pages 153-207.
    18. Pakes, Ariel S, 1986. "Patents as Options: Some Estimates of the Value of Holding European Patent Stocks," Econometrica, Econometric Society, vol. 54(4), pages 755-784, July.
    19. Isaiah Andrews & Maximilian Kasy, 2019. "Identification of and Correction for Publication Bias," American Economic Review, American Economic Association, vol. 109(8), pages 2766-2794, August.
    20. Easterlin, Richard A., 1999. "How beneficent is the market? A look at the modern history of mortality," European Review of Economic History, Cambridge University Press, vol. 3(3), pages 257-294, December.
    21. Ian Goldin & Pantelis Koutroumpis & François Lafond & Julian Winkler, 2024. "Why Is Productivity Slowing Down?," Journal of Economic Literature, American Economic Association, vol. 62(1), pages 196-268, March.
    22. Peter Howitt, 1999. "Steady Endogenous Growth with Population and R & D Inputs Growing," Journal of Political Economy, University of Chicago Press, vol. 107(4), pages 715-730, August.
    23. Leila Agha & David Molitor, 2018. "The Local Influence of Pioneer Investigators on Technology Adoption: Evidence from New Cancer Drugs," The Review of Economics and Statistics, MIT Press, vol. 100(1), pages 29-44, March.
    24. Marcella Alsan & Maya Durvasula & Harsh Gupta & Joshua Schwartzstein & Heidi Williams, 2024. "Representation and Extrapolation: Evidence from Clinical Trials," The Quarterly Journal of Economics, President and Fellows of Harvard College, vol. 139(1), pages 575-635.
    25. Dinopoulos, Elias & Thompson, Peter, 1998. "Schumpeterian Growth without Scale Effects," Journal of Economic Growth, Springer, vol. 3(4), pages 313-335, December.
    26. Kyle Myers & Mark Pauly, 2019. "Endogenous productivity of demand‐induced R&D: evidence from pharmaceuticals," RAND Journal of Economics, RAND Corporation, vol. 50(3), pages 591-614, September.
    27. Danielle Li, 2017. "Expertise versus Bias in Evaluation: Evidence from the NIH," American Economic Journal: Applied Economics, American Economic Association, vol. 9(2), pages 60-92, April.
    28. Kyle Myers, 2020. "The Elasticity of Science," American Economic Journal: Applied Economics, American Economic Association, vol. 12(4), pages 103-134, October.
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