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Hodgkin–Huxley neurons with defective and blocked ion channels

Author

Listed:
  • James Christopher S. Pang

    (National Institute of Physics, University of the Philippines Diliman, Quezon City 1101, Philippines)

  • Johnrob Y. Bantang

    (National Institute of Physics, University of the Philippines Diliman, Quezon City 1101, Philippines)

Abstract

We utilize the original Hodgkin–Huxley (HH) model to consider the effects of defective ion channels to the temporal response of neurons. Statistics of firing rate and inter-spike interval (ISI) reveal that production of action potentials (APs) in neurons is not sensitive to changes in membrane conductance for sodium and potassium ions, as well as to the reversal potential for sodium ions, as long as the relevant parameters do not exceed 13% from their normal levels. We also found that blockage of a critical fraction of either sodium or potassium channels (dependent on constant input current) respectively limits the firing activity or increases spontaneous spiking activity of neurons. Our model may be used to guide experiment designs related to ion channel control drug development.

Suggested Citation

  • James Christopher S. Pang & Johnrob Y. Bantang, 2015. "Hodgkin–Huxley neurons with defective and blocked ion channels," International Journal of Modern Physics C (IJMPC), World Scientific Publishing Co. Pte. Ltd., vol. 26(10), pages 1-14.
    • Handle: RePEc:wsi:ijmpcx:v:26:y:2015:i:10:n:s0129183115501120
    DOI: 10.1142/S0129183115501120
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    Cited by:

    1. Liu, Yaru & Liu, Shenquan & Zhan, Feibiao & Zhang, Xiaohan, 2020. "Firing patterns of the modified Hodgkin–Huxley models subject to Taylor ’s formula," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 547(C).

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