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Part I––Comparing Noncancer Chronic Human Health Reference Values: An Analysis of Science Policy Choices

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  • Elizabeth Holman
  • Royce Francis
  • George Gray

Abstract

The goal of this study was to systematically evaluate the choices made in deriving a chronic oral noncancer human health reference value (HHRV) for a given chemical by different organizations, specifically those from the U.S. Environmental Protection Agency, Health Canada, RIVM (the Netherlands), and the U.S. Agency for Toxic Substances and Disease Registry. This analysis presents a methodological approach for comparing both the HHRVs and the specific choices made in the process of deriving an HHRV across these organizations. Overall, across the 96 unique chemicals and 171 two‐way organizational comparisons, the HHRV agreed approximately 26% of the time. A qualitative method for identifying the primary factors influencing these HHRV differences was also developed, using arrays of HHRVs across organizations for the same chemical. The primary factors identified were disagreement on the critical or principal study and differential application of the total uncertainty factor across organizations. Of the cases where the total UF was the primary factor influencing HHRV disagreement, the database UF had the greatest influence.

Suggested Citation

  • Elizabeth Holman & Royce Francis & George Gray, 2017. "Part I––Comparing Noncancer Chronic Human Health Reference Values: An Analysis of Science Policy Choices," Risk Analysis, John Wiley & Sons, vol. 37(5), pages 861-878, May.
    • Handle: RePEc:wly:riskan:v:37:y:2017:i:5:p:861-878
    DOI: 10.1111/risa.12700
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    References listed on IDEAS

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    1. Jeffrey C. Swartout & Paul S. Price & Michael L. Dourson & Heather L. Carlson‐Lynch & Russell E. Keenan, 1998. "A Probabilistic Framework for the Reference Dose (Probabilistic RfD)," Risk Analysis, John Wiley & Sons, vol. 18(3), pages 271-282, June.
    2. Diana G. Effio & Oliver Kroner & Andrew Maier & William Hayes & Alison Willis & Joan Strawson, 2013. "A Look at State‐Level Risk Assessment in the United States: Making Decisions in the Absence of Federal Risk Values," Risk Analysis, John Wiley & Sons, vol. 33(1), pages 54-67, January.
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