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Estimation and Extrapolation of Tumor Probabilities from a Mouse Bioassay with Survival/Sacrifice Components

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  • John H. Farmer
  • Ralph L. Kodell
  • David W. Gaylor

Abstract

A nonparametric estimator of the probability distribution of time‐to‐tumor is incorporated into an algorithm for calculating linearly extrapolated dosage limits from an animal carcino‐genesis bioassay. The procedure is illustrated with tumor data from a mouse bioassay with 2‐acetylaminofluorene. Extrapolated dosage limits for an excess risk of 10‐6 differ by only a factor of 2 across the six replicates of the experiment.

Suggested Citation

  • John H. Farmer & Ralph L. Kodell & David W. Gaylor, 1982. "Estimation and Extrapolation of Tumor Probabilities from a Mouse Bioassay with Survival/Sacrifice Components," Risk Analysis, John Wiley & Sons, vol. 2(1), pages 27-34, March.
    • Handle: RePEc:wly:riskan:v:2:y:1982:i:1:p:27-34
    DOI: 10.1111/j.1539-6924.1982.tb01400.x
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    Cited by:

    1. D. Krewski & D .W. Gaylor & A. P. Soms & M. Szyszkowicz, 1993. "An Overview of the Report: Correlation Between Carcinogenic Potency and the Maximum Tolerated Dose: Implications for Risk Assessment," Risk Analysis, John Wiley & Sons, vol. 13(4), pages 383-398, August.
    2. John C. Bailar & Edmund A. C. Crouch & Rashid Shaikh & Donna Spiegelman, 1988. "One‐Hit Models of Carcinogenesis: Conservative or Not?," Risk Analysis, John Wiley & Sons, vol. 8(4), pages 485-497, December.
    3. David W. Gaylor & Ralph L. Kodell & James J. Chen & Janet A. Springer & Ronald J. Lorentzen & Robert J. Scheuplein, 1994. "Point Estimates of Cancer Risk at Low Doses," Risk Analysis, John Wiley & Sons, vol. 14(5), pages 843-850, October.
    4. Ralph L. Kodell & James J. Chen, 1994. "Reducing Conservatism in Risk Estimation for Mixtures of Carcinogens," Risk Analysis, John Wiley & Sons, vol. 14(3), pages 327-332, June.
    5. David W. Gaylor, 1982. "Response to Mantel," Risk Analysis, John Wiley & Sons, vol. 2(3), pages 117-118, September.
    6. Nathan Mantel, 1982. "Extrapolation of Tumor Probabilities," Risk Analysis, John Wiley & Sons, vol. 2(3), pages 115-116, September.

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