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Tests for Trend in Developmental Toxicity Experiments with Correlated Binary Data

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  • K. Y. Fung
  • D. Krewski
  • J. N. K. Rao
  • A. J. Scott

Abstract

In this article, the operating characteristics of recently proposed tests for trend in correlated binary data arising in laboratory studies of developmental toxicity are examined using both computer‐generated and experimental data. Specifically, we consider adjusted Cochran‐Armitgc tests based on the Rao‐Scott transformation which are of the same general form as that for uncorrelated data. In addition, generalized score tests based on generalized estimating equations allowing for extra‐binomial variation in the data are discussed. Specific forms of these statistics demonstrating favorable type I and type II error rates are identified and recommended for use in practice. The application of these tests is illustrated using data from studies of developmental toxicity that have been reported in the literature.

Suggested Citation

  • K. Y. Fung & D. Krewski & J. N. K. Rao & A. J. Scott, 1994. "Tests for Trend in Developmental Toxicity Experiments with Correlated Binary Data," Risk Analysis, John Wiley & Sons, vol. 14(4), pages 639-648, August.
    • Handle: RePEc:wly:riskan:v:14:y:1994:i:4:p:639-648
    DOI: 10.1111/j.1539-6924.1994.tb00277.x
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    References listed on IDEAS

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    1. A. J. Scott & T. M. F. Smith, 1971. "Interval Estimates for Linear Combinations of Means," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 20(3), pages 276-285, November.
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    Cited by:

    1. Karen Y. Fung & Leonora Marro & Daniel Krewski, 1998. "A Comparison of Methods for Estimating the Benchmark Dose Based on Overdispersed Data from Developmental Toxicity Studies," Risk Analysis, John Wiley & Sons, vol. 18(3), pages 329-342, June.
    2. John F. Fox & Karen A. Hogan & Allen Davis, 2017. "Dose‐Response Modeling with Summary Data from Developmental Toxicity Studies," Risk Analysis, John Wiley & Sons, vol. 37(5), pages 905-917, May.
    3. D. Krewski & Y. Zhu, 1995. "A Simple Data Transformation for Estimating Benchmark Doses in Developmental Toxicity Experiments," Risk Analysis, John Wiley & Sons, vol. 15(1), pages 29-39, February.
    4. Ahn, Chul, 1997. "An evaluation of simple methods for the estimation of a common odds ratio in clusters with variable size," Computational Statistics & Data Analysis, Elsevier, vol. 24(1), pages 47-61, March.

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