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Risk Assessment for Aflatoxin: An Evaluation Based on the Multistage Model

Author

Listed:
  • J. Bowers
  • B. Brown
  • J. Springer
  • L. Tollefson
  • R. Lorentzen
  • S. Henry

Abstract

Lifetime cancer potency of alfatoxin was assessed based on the Yeh et al. study from China in which both aflatoxin exposure and hepatitis B prevalence were measured. This study provides the best available information for estimating the carcinogenic risk posed by aflatoxin to the U.S. population. Cancer potency of aflatoxin was estimated using a biologically motivated risk assessment model. The best estimate of aflatoxin potency was 9 (mg/kg/day)−1 for individuals negative for hepatitis B and 230 (mg/kg/day)−1 for individuals positive for hepatitis B.

Suggested Citation

  • J. Bowers & B. Brown & J. Springer & L. Tollefson & R. Lorentzen & S. Henry, 1993. "Risk Assessment for Aflatoxin: An Evaluation Based on the Multistage Model," Risk Analysis, John Wiley & Sons, vol. 13(6), pages 637-642, December.
    • Handle: RePEc:wly:riskan:v:13:y:1993:i:6:p:637-642
    DOI: 10.1111/j.1539-6924.1993.tb01325.x
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    References listed on IDEAS

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    1. Anna H. Wu‐Williams & Lauren Zeise & Duncan Thomas, 1992. "Risk Assessment for Aflatoxin B1: A Modeling Approach," Risk Analysis, John Wiley & Sons, vol. 12(4), pages 559-567, December.
    2. Mohammad S. Hoseyni, 1992. "Risk Assessment for Aflatoxin: III. Modeling the Relative Risk of Hepatocellular Carcinoma," Risk Analysis, John Wiley & Sons, vol. 12(1), pages 123-128, March.
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    Cited by:

    1. Gao, Jiti & Tong, Howell & Wolff, Rodney, 2002. "Model Specification Tests in Nonparametric Stochastic Regression Models," Journal of Multivariate Analysis, Elsevier, vol. 83(2), pages 324-359, November.
    2. David W. Gaylor & Ralph L. Kodell & James J. Chen & Janet A. Springer & Ronald J. Lorentzen & Robert J. Scheuplein, 1994. "Point Estimates of Cancer Risk at Low Doses," Risk Analysis, John Wiley & Sons, vol. 14(5), pages 843-850, October.
    3. Noreddine Benkerroum, 2020. "Aflatoxins: Producing-Molds, Structure, Health Issues and Incidence in Southeast Asian and Sub-Saharan African Countries," IJERPH, MDPI, vol. 17(4), pages 1-40, February.
    4. Yang, Yuhong, 2000. "Combining Different Procedures for Adaptive Regression," Journal of Multivariate Analysis, Elsevier, vol. 74(1), pages 135-161, July.

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    1. Anna H. Wu‐Williams & Lauren Zeise & Duncan Thomas, 1992. "Risk Assessment for Aflatoxin B1: A Modeling Approach," Risk Analysis, John Wiley & Sons, vol. 12(4), pages 559-567, December.
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