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Bayesian Accelerated Failure Time and its Application in Chemotherapy Drug Treatment Trial

Author

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  • Prabhash Kumar

    (Department of Medical Oncology, Tata Memorial Hospital, Bangalore, ; India)

  • Patil Vijay M

    (Department of Medical Oncology, Tata Memorial Hospital, Bangalore, ; India)

  • Noronha Vanita

    (Department of Medical Oncology, Tata Memorial Hospital, Bangalore, ; India)

  • Joshi Amit

    (Department of Medical Oncology, Tata Memorial Hospital, Bangalore, ; India)

  • Bhattacharjee Atanu

    (Department of Biometrics, Chiltern Clinical Research Ltd, Bangalore, Bangalore, ; India)

Abstract

The Cox proportional hazards model (CPH) is normally applied in clinical trial data analysis, but it can generate severe problems with breaking the proportion hazard assumption. An accelerated failure time (AFT) is considered as an alternative to the proportional hazard model. The model can be used through consideration of different covariates of interest and random effects in each section. The model is simple to fit by using OpenBugs software and is revealed to be a good fit to the Chemotherapy data.

Suggested Citation

  • Prabhash Kumar & Patil Vijay M & Noronha Vanita & Joshi Amit & Bhattacharjee Atanu, 2016. "Bayesian Accelerated Failure Time and its Application in Chemotherapy Drug Treatment Trial," Statistics in Transition New Series, Statistics Poland, vol. 17(4), pages 671-690, December.
    • Handle: RePEc:vrs:stintr:v:17:y:2016:i:4:p:671-690:n:14
    DOI: 10.21307/stattrans-2016-046
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    References listed on IDEAS

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