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Identification of longitudinal biomarkers for survival by a score test derived from a joint model of longitudinal and competing risks data

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  • Feng-Shou Ko

Abstract

In this paper, we consider joint modelling of repeated measurements and competing risks failure time data. For competing risks time data, a semiparametric mixture model in which proportional hazards model are specified for failure time models conditional on cause and a multinomial model for the marginal distribution of cause conditional on covariates. We also derive a score test based on joint modelling of repeated measurements and competing risks failure time data to identify longitudinal biomarkers or surrogates for a time to event outcome in competing risks data.

Suggested Citation

  • Feng-Shou Ko, 2014. "Identification of longitudinal biomarkers for survival by a score test derived from a joint model of longitudinal and competing risks data," Journal of Applied Statistics, Taylor & Francis Journals, vol. 41(10), pages 2270-2281, October.
  • Handle: RePEc:taf:japsta:v:41:y:2014:i:10:p:2270-2281
    DOI: 10.1080/02664763.2014.909789
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    Cited by:

    1. Graeme L. Hickey & Pete Philipson & Andrea Jorgensen & Ruwanthi Kolamunnage‐Dona, 2018. "A comparison of joint models for longitudinal and competing risks data, with application to an epilepsy drug randomized controlled trial," Journal of the Royal Statistical Society Series A, Royal Statistical Society, vol. 181(4), pages 1105-1123, October.

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