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Cross-bridge mechanism of residual force enhancement after stretching in a skeletal muscle

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  • Youjiro Tamura

Abstract

A muscle model that uses a modified Langevin equation with actomyosin potentials was used to describe the residual force enhancement after active stretching. Considering that the new model uses cross-bridge theory to describe the residual force enhancement, it is different from other models that use passive stretching elements. Residual force enhancement was simulated using a half sarcomere comprising 100 myosin molecules. In this paper, impulse is defined as the integral of an excess force from the steady isometric force over the time interval for which a stretch is applied. The impulse was calculated from the force response due to fast and slow muscle stretches to demonstrate the viscoelastic property of the cross-bridges. A cross-bridge mechanism was proposed as a way to describe the residual force enhancement on the basis of the impulse results with reference to the compliance of the actin filament. It was assumed that the period of the actin potential increased by 0.5% and the amplitude of the potential decreased by 0.5% when the half sarcomere was stretched by 10%. The residual force enhancement after 21.0% sarcomere stretching was 6.9% of the maximum isometric force of the muscle; this value was due to the increase in the number of cross-bridges.

Suggested Citation

  • Youjiro Tamura, 2018. "Cross-bridge mechanism of residual force enhancement after stretching in a skeletal muscle," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 21(1), pages 75-82, January.
    • Handle: RePEc:taf:gcmbxx:v:21:y:2018:i:1:p:75-82
    DOI: 10.1080/10255842.2018.1424837
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    References listed on IDEAS

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    1. Gudrun Schappacher-Tilp & Timothy Leonard & Gertrud Desch & Walter Herzog, 2015. "A Novel Three-Filament Model of Force Generation in Eccentric Contraction of Skeletal Muscles," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-16, March.
    2. Yoshikazu Suzuki & Takuo Yasunaga & Reiko Ohkura & Takeyuki Wakabayashi & Kazuo Sutoh, 1998. "Swing of the lever arm of a myosin motor at the isomerization and phosphate-release steps," Nature, Nature, vol. 396(6709), pages 380-383, November.
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