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A Novel Three-Filament Model of Force Generation in Eccentric Contraction of Skeletal Muscles

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  • Gudrun Schappacher-Tilp
  • Timothy Leonard
  • Gertrud Desch
  • Walter Herzog

Abstract

We propose and examine a three filament model of skeletal muscle force generation, thereby extending classical cross-bridge models by involving titin-actin interaction upon active force production. In regions with optimal actin-myosin overlap, the model does not alter energy and force predictions of cross-bridge models for isometric contractions. However, in contrast to cross-bridge models, the three filament model accurately predicts history-dependent force generation in half sarcomeres for eccentric and concentric contractions, and predicts the activation-dependent forces for stretches beyond actin-myosin filament overlap.

Suggested Citation

  • Gudrun Schappacher-Tilp & Timothy Leonard & Gertrud Desch & Walter Herzog, 2015. "A Novel Three-Filament Model of Force Generation in Eccentric Contraction of Skeletal Muscles," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-16, March.
    • Handle: RePEc:plo:pone00:0117634
    DOI: 10.1371/journal.pone.0117634
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    References listed on IDEAS

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    1. Hongbin Li & Wolfgang A. Linke & Andres F. Oberhauser & Mariano Carrion-Vazquez & Jason G. Kerkvliet & Hui Lu & Piotr E. Marszalek & Julio M. Fernandez, 2002. "Reverse engineering of the giant muscle protein titin," Nature, Nature, vol. 418(6901), pages 998-1002, August.
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    Cited by:

    1. Youjiro Tamura, 2018. "Cross-bridge mechanism of residual force enhancement after stretching in a skeletal muscle," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 21(1), pages 75-82, January.

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