IDEAS home Printed from https://ideas.repec.org/a/taf/gcmbxx/v18y2015i6p662-675.html
   My bibliography  Save this article

Numerical model for intraosseous infusion of the human calvarium for hydrocephalus shunting

Author

Listed:
  • E. Nzekwu
  • M. Louie
  • D. Scott
  • H. Lundgren
  • J.A. Pugh
  • L.W. Kostiuk
  • J.P. Carey

Abstract

Hydrocephaly is the defective absorption of cerebrospinal fluid (CSF) into the blood stream. This work is an experimental and computational fluid dynamic modelling study to determine the permeability of the diploë as a potential receptor for CSF. Human calvariae were studied by micro-CT to measure their porosity, the area of flow and develop model geometry. Pressure-flow measurements were conducted on specimens to determine their permeability in the physiological and transverse flow directions to compare with numerical results. The overall porosity and permeability of the calvaria were spatially variable. Results suggest an order of magnitude increase in permeability for a 14% increase in overall porosity based on a small number of samples. Numerical results fell within the experimental infusion tests results. Due to the difficulty and ethical considerations in obtaining adolescent skull samples to perform large-scale testing, the developed model will be invaluable.

Suggested Citation

  • E. Nzekwu & M. Louie & D. Scott & H. Lundgren & J.A. Pugh & L.W. Kostiuk & J.P. Carey, 2015. "Numerical model for intraosseous infusion of the human calvarium for hydrocephalus shunting," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 18(6), pages 662-675, April.
    • Handle: RePEc:taf:gcmbxx:v:18:y:2015:i:6:p:662-675
    DOI: 10.1080/10255842.2013.834894
    as

    Download full text from publisher

    File URL: http://hdl.handle.net/10.1080/10255842.2013.834894
    Download Restriction: Access to full text is restricted to subscribers.
    File URL: https://libkey.io/10.1080/10255842.2013.834894?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Jeremy Teo & Swee Teoh, 2012. "Permeability study of vertebral cancellous bone using micro-computational fluid dynamics," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 15(4), pages 417-423.
    2. Marianne Schmid Daners & Verena Knobloch & Michaela Soellinger & Peter Boesiger & Burkhardt Seifert & Lino Guzzella & Vartan Kurtcuoglu, 2012. "Age-Specific Characteristics and Coupling of Cerebral Arterial Inflow and Cerebrospinal Fluid Dynamics," PLOS ONE, Public Library of Science, vol. 7(5), pages 1-10, May.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Taha M Mehemed & Yasutaka Fushimi & Tomohisa Okada & Akira Yamamoto & Mitsunori Kanagaki & Aki Kido & Koji Fujimoto & Naotaka Sakashita & Kaori Togashi, 2014. "Dynamic Oxygen-Enhanced MRI of Cerebrospinal Fluid," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-6, June.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:taf:gcmbxx:v:18:y:2015:i:6:p:662-675. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Chris Longhurst (email available below). General contact details of provider: http://www.tandfonline.com/gcmb .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.