IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0037502.html
   My bibliography  Save this article

Age-Specific Characteristics and Coupling of Cerebral Arterial Inflow and Cerebrospinal Fluid Dynamics

Author

Listed:
  • Marianne Schmid Daners
  • Verena Knobloch
  • Michaela Soellinger
  • Peter Boesiger
  • Burkhardt Seifert
  • Lino Guzzella
  • Vartan Kurtcuoglu

Abstract

The objective of this work is to quantify age-related differences in the characteristics and coupling of cerebral arterial inflow and cerebrospinal fluid (CSF) dynamics. To this end, 3T phase-contrast magnetic resonance imaging blood and CSF flow data of eleven young ( years) and eleven elderly subjects ( years) with a comparable sex-ratio were acquired. Flow waveforms and their frequency composition, transfer functions from blood to CSF flows and cross-correlations were analyzed. The magnitudes of the frequency components of CSF flow in the aqueduct differ significantly between the two age groups, as do the frequency components of the cervical spinal CSF and the arterial flows. The males' aqueductal CSF stroke volumes and average flow rates are significantly higher than those of the females. Transfer functions and cross-correlations between arterial blood and CSF flow reveal significant age-dependence of phase-shift between these, as do the waveforms of arterial blood, as well as cervical-spinal and aqueductal CSF flows. These findings accentuate the need for age- and sex-matched control groups for the evaluation of cerebral pathologies such as hydrocephalus.

Suggested Citation

  • Marianne Schmid Daners & Verena Knobloch & Michaela Soellinger & Peter Boesiger & Burkhardt Seifert & Lino Guzzella & Vartan Kurtcuoglu, 2012. "Age-Specific Characteristics and Coupling of Cerebral Arterial Inflow and Cerebrospinal Fluid Dynamics," PLOS ONE, Public Library of Science, vol. 7(5), pages 1-10, May.
    • Handle: RePEc:plo:pone00:0037502
    DOI: 10.1371/journal.pone.0037502
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0037502
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0037502&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0037502?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. E. Nzekwu & M. Louie & D. Scott & H. Lundgren & J.A. Pugh & L.W. Kostiuk & J.P. Carey, 2015. "Numerical model for intraosseous infusion of the human calvarium for hydrocephalus shunting," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 18(6), pages 662-675, April.
    2. Taha M Mehemed & Yasutaka Fushimi & Tomohisa Okada & Akira Yamamoto & Mitsunori Kanagaki & Aki Kido & Koji Fujimoto & Naotaka Sakashita & Kaori Togashi, 2014. "Dynamic Oxygen-Enhanced MRI of Cerebrospinal Fluid," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-6, June.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0037502. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.