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Evaluating Cost-Effectiveness of Antiretroviral Therapy over Time: A Cohort and Cost-Effectiveness Study

Author

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  • Matilde Slot

    (Nordic Institute of Health Economics
    Aarhus University
    Aarhus University Hospital
    Aarhus University)

  • Thomas Bøjer Rasmussen

    (Aarhus University Hospital
    Aarhus University)

  • Mette Nørgaard

    (Aarhus University Hospital
    Aarhus University)

  • Carsten Schade Larsen

    (Aarhus University Hospital)

  • Lars Holger Ehlers

    (Nordic Institute of Health Economics)

Abstract

Objective To estimate the costs and cost-effectiveness of introducing highly active antiretroviral therapy (HAART) in Denmark based on real-world evidence for the three treatment eras pre-HAART (1985–1995), early HAART (1996–2005), and late HAART (2006–2017). Methods We performed a cohort study using Danish clinical and administrative registries to estimate costs, quality-adjusted life-years (QALYs), and life-years (LY) gained per person living with human immunodeficiency virus (PLHIV) in three treatment eras. The study utilized Markov modeling for a health economic evaluation, which summarized inputs from real-world evidence and estimated the cost-effectiveness in 2017 prices of the introduction of HAART in Denmark. We performed deterministic and probabilistic sensitivity analyses to assess the robustness of the results. Results The total annual costs per PLHIV increased with the introduction of HAART for the index year but decreased in the incremental years and the last year of life. The total lifetime discounted (and undiscounted) cost for an average PLHIV was €91,010 (€128,981) in pre-HAART, €103,130 (€199,062) in early HAART, and €126,317 (€254,964) in late HAART. The estimated incremental cost-effectiveness ratios showed that early HAART was cost-effective compared with pre-HAART with an incremental cost-effectiveness ratio (ICER) of €1378 per QALY, and that late HAART was cost-effective compared with early HAART with an ICER of €7385 per QALY. Sensitivity analyses confirmed cost-effectiveness in all scenarios. Conclusions The introduction and implementation of HAART in Danish healthcare was cost-effective, and in some scenarios, even disruptive, i.e., led to both cheaper and more effective care of PLHIV.

Suggested Citation

  • Matilde Slot & Thomas Bøjer Rasmussen & Mette Nørgaard & Carsten Schade Larsen & Lars Holger Ehlers, 2024. "Evaluating Cost-Effectiveness of Antiretroviral Therapy over Time: A Cohort and Cost-Effectiveness Study," PharmacoEconomics - Open, Springer, vol. 8(6), pages 847-856, November.
    • Handle: RePEc:spr:pharmo:v:8:y:2024:i:6:d:10.1007_s41669-024-00513-7
    DOI: 10.1007/s41669-024-00513-7
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    References listed on IDEAS

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    1. Bruce R. Schackman & Sue J. Goldie & Kenneth A. Freedberg & Elena Losina & John Brazier & Milton C. Weinstein, 2002. "Comparison of Health State Utilities Using Community and Patient Preference Weights Derived from a Survey of Patients with HIV/AIDS," Medical Decision Making, , vol. 22(1), pages 27-38, February.
    2. Drummond, Michael F. & Sculpher, Mark J. & Claxton, Karl & Stoddart, Greg L. & Torrance, George W., 2015. "Methods for the Economic Evaluation of Health Care Programmes," OUP Catalogue, Oxford University Press, edition 4, number 9780199665884.
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