IDEAS home Printed from https://ideas.repec.org/a/spr/lifeda/v26y2020i4d10.1007_s10985-020-09495-0.html
   My bibliography  Save this article

Estimation of treatment effects and model diagnostics with two-way time-varying treatment switching: an application to a head and neck study

Author

Listed:
  • Qingxia Chen

    (Vanderbilt University Medical Center)

  • Fan Zhang

    (Pfizer Inc.)

  • Ming-Hui Chen

    (University of Connecticut)

  • Xiuyu Julie Cong

    (Everest Medicines)

Abstract

Treatment switching frequently occurs in clinical trials due to ethical reasons. Intent-to-treat analysis without adjusting for switching yields biased and inefficient estimates of the treatment effects. In this paper, we propose a class of semiparametric semi-competing risks transition survival models to accommodate two-way time-varying switching. Theoretical properties of the proposed method are examined. An efficient expectation–maximization algorithm is derived to obtain maximum likelihood estimates and model diagnostic tools. Existing software is used to implement the algorithm. Simulation studies are conducted to demonstrate the validity of the model. The proposed method is further applied to data from a clinical trial with patients having recurrent or metastatic squamous-cell carcinoma of head and neck.

Suggested Citation

  • Qingxia Chen & Fan Zhang & Ming-Hui Chen & Xiuyu Julie Cong, 2020. "Estimation of treatment effects and model diagnostics with two-way time-varying treatment switching: an application to a head and neck study," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 26(4), pages 685-707, October.
    • Handle: RePEc:spr:lifeda:v:26:y:2020:i:4:d:10.1007_s10985-020-09495-0
    DOI: 10.1007/s10985-020-09495-0
    as

    Download full text from publisher

    File URL: http://link.springer.com/10.1007/s10985-020-09495-0
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1007/s10985-020-09495-0?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Baqun Zhang & Anastasios A. Tsiatis & Eric B. Laber & Marie Davidian, 2012. "A Robust Method for Estimating Optimal Treatment Regimes," Biometrics, The International Biometric Society, vol. 68(4), pages 1010-1018, December.
    2. S. A. Murphy, 2003. "Optimal dynamic treatment regimes," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 65(2), pages 331-355, May.
    3. Ying-Qi Zhao & Donglin Zeng & Eric B. Laber & Michael R. Kosorok, 2015. "New Statistical Learning Methods for Estimating Optimal Dynamic Treatment Regimes," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 110(510), pages 583-598, June.
    4. Donglin Zeng & Qingxia Chen & Ming-Hui Chen & Joseph G. Ibrahim, 2012. "Estimating treatment effects with treatment switching via semicompeting risks models: an application to a colorectal cancer study," Biometrika, Biometrika Trust, vol. 99(1), pages 167-184.
    5. James M. Robins & Dianne M. Finkelstein, 2000. "Correcting for Noncompliance and Dependent Censoring in an AIDS Clinical Trial with Inverse Probability of Censoring Weighted (IPCW) Log-Rank Tests," Biometrics, The International Biometric Society, vol. 56(3), pages 779-788, September.
    6. J. G. Ibrahim & S. R. Lipsitz & M.‐H. Chen, 1999. "Missing covariates in generalized linear models when the missing data mechanism is non‐ignorable," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 61(1), pages 173-190.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Deqing Wang & Qian Huang & Tianzhi Ye & Sihua Tian, 2021. "Research on the Two-Way Time-Varying Relationship between Foreign Direct Investment and Financial Development Based on Functional Data Analysis," Sustainability, MDPI, vol. 13(11), pages 1-23, May.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Xin Qiu & Donglin Zeng & Yuanjia Wang, 2018. "Estimation and evaluation of linear individualized treatment rules to guarantee performance," Biometrics, The International Biometric Society, vol. 74(2), pages 517-528, June.
    2. Zhen Li & Jie Chen & Eric Laber & Fang Liu & Richard Baumgartner, 2023. "Optimal Treatment Regimes: A Review and Empirical Comparison," International Statistical Review, International Statistical Institute, vol. 91(3), pages 427-463, December.
    3. Hyung Park & Eva Petkova & Thaddeus Tarpey & R. Todd Ogden, 2021. "A constrained single‐index regression for estimating interactions between a treatment and covariates," Biometrics, The International Biometric Society, vol. 77(2), pages 506-518, June.
    4. Yebin Tao & Lu Wang, 2017. "Adaptive contrast weighted learning for multi-stage multi-treatment decision-making," Biometrics, The International Biometric Society, vol. 73(1), pages 145-155, March.
    5. Kara E. Rudolph & Iván Díaz, 2022. "When the ends do not justify the means: Learning who is predicted to have harmful indirect effects," Journal of the Royal Statistical Society Series A, Royal Statistical Society, vol. 185(S2), pages 573-589, December.
    6. Yunan Wu & Lan Wang, 2021. "Resampling‐based confidence intervals for model‐free robust inference on optimal treatment regimes," Biometrics, The International Biometric Society, vol. 77(2), pages 465-476, June.
    7. Shi, Chengchun & Wan, Runzhe & Song, Ge & Luo, Shikai & Zhu, Hongtu & Song, Rui, 2023. "A multiagent reinforcement learning framework for off-policy evaluation in two-sided markets," LSE Research Online Documents on Economics 117174, London School of Economics and Political Science, LSE Library.
    8. Kristin A. Linn & Eric B. Laber & Leonard A. Stefanski, 2017. "Interactive -Learning for Quantiles," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 112(518), pages 638-649, April.
    9. Rebecca Hager & Anastasios A. Tsiatis & Marie Davidian, 2018. "Optimal two‐stage dynamic treatment regimes from a classification perspective with censored survival data," Biometrics, The International Biometric Society, vol. 74(4), pages 1180-1192, December.
    10. Shuxiao Chen & Bo Zhang, 2021. "Estimating and Improving Dynamic Treatment Regimes With a Time-Varying Instrumental Variable," Papers 2104.07822, arXiv.org.
    11. Ruoqing Zhu & Ying-Qi Zhao & Guanhua Chen & Shuangge Ma & Hongyu Zhao, 2017. "Greedy outcome weighted tree learning of optimal personalized treatment rules," Biometrics, The International Biometric Society, vol. 73(2), pages 391-400, June.
    12. Weibin Mo & Yufeng Liu, 2022. "Efficient learning of optimal individualized treatment rules for heteroscedastic or misspecified treatment‐free effect models," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 84(2), pages 440-472, April.
    13. Shosei Sakaguchi, 2021. "Estimation of Optimal Dynamic Treatment Assignment Rules under Policy Constraints," Papers 2106.05031, arXiv.org, revised Aug 2024.
    14. Yizhe Xu & Tom H. Greene & Adam P. Bress & Brian C. Sauer & Brandon K. Bellows & Yue Zhang & William S. Weintraub & Andrew E. Moran & Jincheng Shen, 2022. "Estimating the optimal individualized treatment rule from a cost‐effectiveness perspective," Biometrics, The International Biometric Society, vol. 78(1), pages 337-351, March.
    15. Yaoyao Xu & Menggang Yu & Ying‐Qi Zhao & Quefeng Li & Sijian Wang & Jun Shao, 2015. "Regularized outcome weighted subgroup identification for differential treatment effects," Biometrics, The International Biometric Society, vol. 71(3), pages 645-653, September.
    16. Jincheng Shen & Lu Wang & Jeremy M. G. Taylor, 2017. "Estimation of the optimal regime in treatment of prostate cancer recurrence from observational data using flexible weighting models," Biometrics, The International Biometric Society, vol. 73(2), pages 635-645, June.
    17. Muxuan Liang & Menggang Yu, 2023. "Relative contrast estimation and inference for treatment recommendation," Biometrics, The International Biometric Society, vol. 79(4), pages 2920-2932, December.
    18. Baqun Zhang & Min Zhang, 2018. "C‐learning: A new classification framework to estimate optimal dynamic treatment regimes," Biometrics, The International Biometric Society, vol. 74(3), pages 891-899, September.
    19. Michael C Knaus & Michael Lechner & Anthony Strittmatter, 2021. "Machine learning estimation of heterogeneous causal effects: Empirical Monte Carlo evidence," The Econometrics Journal, Royal Economic Society, vol. 24(1), pages 134-161.
    20. Michael C. Knaus & Michael Lechner & Anthony Strittmatter, 2022. "Heterogeneous Employment Effects of Job Search Programs: A Machine Learning Approach," Journal of Human Resources, University of Wisconsin Press, vol. 57(2), pages 597-636.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:spr:lifeda:v:26:y:2020:i:4:d:10.1007_s10985-020-09495-0. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.springer.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.