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The Molecular Genetics of Life Satisfaction: Extending Findings from a Recent Genome-Wide Association Study and Examining the Role of the Serotonin Transporter

Author

Listed:
  • Bernd Lachmann

    (Ulm University)

  • Anna Doebler

    (University of Mannheim)

  • Cornelia Sindermann

    (Ulm University)

  • Rayna Sariyska

    (Ulm University)

  • Andrew Cooper

    (Goldsmiths, University of London)

  • Heidrun Haas

    (Ulm University)

  • Christian Montag

    (Ulm University)

Abstract

In a recent genome-wide association study (GWAS), three polymorphisms (rs3756290, RAPGEF6; rs2075677, CSE1L; rs4958581, NMUR2) were suggested as potentially being related to subjective-well-being and life satisfaction. Additionally, associations between the 5-HTTLPR polymorphism (serotonin transporter) and subjective well-being have been reported in other previous studies. In the current study, we therefore sought to further investigate the findings of the GWAS and examine the association between 5-HTTLPR and subjective well-being. A total of 1174 participants (821 females) were recruited and asked to provide information on their demographics, life satisfaction, and positive affect. All participants provided a genetic sample. We found associations between one SNP derived from the GWAS (rs4958581, NMUR2) and life satisfaction. We also replicated findings involving 5-HTTLPR and life satisfaction, but only for the housing, leisure and family life satisfaction variables, and not for overall life satisfaction or positive affect. Our study underlines that research investigating complex traits in the field of behavioral genetics is challenging due to their (a) pleiotropic and (b) polygenic effects, resulting in tiny effect sizes of each marker investigated. The current study also highlights the importance of investigating genetic markers of distinct areas of life satisfaction.

Suggested Citation

  • Bernd Lachmann & Anna Doebler & Cornelia Sindermann & Rayna Sariyska & Andrew Cooper & Heidrun Haas & Christian Montag, 2021. "The Molecular Genetics of Life Satisfaction: Extending Findings from a Recent Genome-Wide Association Study and Examining the Role of the Serotonin Transporter," Journal of Happiness Studies, Springer, vol. 22(1), pages 305-322, January.
    • Handle: RePEc:spr:jhappi:v:22:y:2021:i:1:d:10.1007_s10902-020-00231-x
    DOI: 10.1007/s10902-020-00231-x
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    References listed on IDEAS

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    1. Bruce Headey & Ruut Veenhoven & Alex Wearing, 1991. "Top-down versus bottom-up theories of subjective well-being," Social Indicators Research: An International and Interdisciplinary Journal for Quality-of-Life Measurement, Springer, vol. 24(1), pages 81-100, February.
    2. Jan-Emmanuel De Neve & James H. Fowler & Bruno S. Frey, 2010. "Genes, economics, and happiness," IEW - Working Papers 475, Institute for Empirical Research in Economics - University of Zurich.
    3. López Ulloa, Beatriz Fabiola & Møller, Valerie & Sousa-Poza, Alfonso, 2013. "How does subjective well-being evolve with age? A literature review," FZID Discussion Papers 72-2013, University of Hohenheim, Center for Research on Innovation and Services (FZID).
    4. Thomas Siedler & Jürgen Schupp & C. Katharina Spiess & Gert G. Wagner, 2008. "The German Socio-Economic Panel as Reference Data Set," RatSWD Working Papers 48, German Data Forum (RatSWD).
    5. Adam Shapiro & Corey Keyes, 2008. "Marital Status and Social Well-Being: Are the Married Always Better Off?," Social Indicators Research: An International and Interdisciplinary Journal for Quality-of-Life Measurement, Springer, vol. 88(2), pages 329-346, September.
    6. Nansook Park & E. Huebner & James Laughlin & Robert Valois & Rich Gilman, 2004. "A Cross-cultural Comparison of the Dimensions of Child and Adolescent Life Satisfaction Reports," Social Indicators Research: An International and Interdisciplinary Journal for Quality-of-Life Measurement, Springer, vol. 66(1), pages 61-79, April.
    7. Magnus Johannesson & David I. Laibson & Sarah E. Medland & Michelle N. Meyer & Joseph K. Pickrell & Tõnu Esko & Robert F. Krueger & Jonathan P. Beauchamp & Philipp D. Koellinger & Daniel J. Benjamin &, 2016. "Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses," Post-Print hal-02017373, HAL.
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