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Health state utilities associated with post-surgical Staphylococcus aureus infections

Author

Listed:
  • Louis S. Matza

    (Evidera)

  • Katherine J. Kim

    (Evidera)

  • Holly Yu

    (Pfizer Inc)

  • Katherine A. Belden

    (Thomas Jefferson University)

  • Antonia F. Chen

    (Harvard Medical School)

  • Mark Kurd

    (Thomas Jefferson University The Rothman Institute)

  • Bruce Y. Lee

    (Johns Hopkins University Bloomberg School of Public Health)

  • Jason Webb

    (Southmead Hospital)

Abstract

Introduction Surgical site infections (SSIs) are among the most common and potentially serious complications after surgery. Staphylococcus aureus is a virulent pathogen frequently identified as a cause of SSI. As vaccines and other infection control measures are developed to reduce SSI risk, cost-utility analyses (CUA) of these interventions are needed to inform resource allocation decisions. A recent systematic review found that available SSI utilities are of “questionable quality.” Therefore, the purpose of this study was to estimate the disutility (i.e., utility decrease) associated with SSIs. Methods In time trade-off interviews, general population participants in the UK (London, Edinburgh) valued health states drafted based on literature and clinician interviews. Health states described either joint or spine surgery, with or without an SSI. The utility difference between otherwise identical health states with and without the SSI represented the disutility associated with the SSI. Results A total of 201 participants completed interviews (50.2% female; mean age = 46.2 years). Mean (SD) utilities of health states describing joint and spine surgery without infections were 0.79 (0.23) and 0.78 (0.23). Disutilities of SSIs ranged from − 0.03 to − 0.32, depending on severity of the infection and subsequent medical interventions. All differences between corresponding health with and without SSIs were statistically significant (all p

Suggested Citation

  • Louis S. Matza & Katherine J. Kim & Holly Yu & Katherine A. Belden & Antonia F. Chen & Mark Kurd & Bruce Y. Lee & Jason Webb, 2019. "Health state utilities associated with post-surgical Staphylococcus aureus infections," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 20(6), pages 819-827, August.
  • Handle: RePEc:spr:eujhec:v:20:y:2019:i:6:d:10.1007_s10198-019-01036-3
    DOI: 10.1007/s10198-019-01036-3
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    References listed on IDEAS

    as
    1. Brazier, John & Ratcliffe, Julie & Salomon, Joshua & Tsuchiya, Aki, 2016. "Measuring and Valuing Health Benefits for Economic Evaluation," OUP Catalogue, Oxford University Press, edition 2, number 9780198725923.
    2. Louis S. Matza & Kristina S. Boye & David H. Feeny & Lee Bowman & Joseph A. Johnston & Katie D. Stewart & Kelly McDaniel & Jessica Jordan, 2016. "The time horizon matters: results of an exploratory study varying the timeframe in time trade-off and standard gamble utility elicitation," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 17(8), pages 979-990, November.
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    More about this item

    Keywords

    Utility; Time trade-off; Surgical site infection; SSI; Surgery; Staphylococcus aureus;
    All these keywords.

    JEL classification:

    • I00 - Health, Education, and Welfare - - General - - - General

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