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EQ-5D studies in nervous system diseases in eight Central and East European countries: a systematic literature review

Author

Listed:
  • Valentina Prevolnik Rupel

    (Institute for Economic Research)

  • Marko Divjak

    (DOBA Business School)

  • Zsombor Zrubka

    (Corvinus University of Budapest
    Corvinus University of Budapest)

  • Fanni Rencz

    (Corvinus University of Budapest
    Hungarian Academy of Sciences)

  • László Gulácsi

    (Corvinus University of Budapest)

  • Dominik Golicki

    (Medical University of Warsaw, Poland)

  • Dagmara Mirowska-Guzel

    (Medical University of Warsaw, Poland)

  • Judit Simon

    (Medical University of Vienna)

  • Valentin Brodszky

    (Corvinus University of Budapest)

  • Petra Baji

    (Corvinus University of Budapest)

  • Jakub Závada

    (Institute of Rheumatology)

  • Guenka Petrova

    (Medical University)

  • Alexandru Rotar

    (University of Amsterdam)

  • Márta Péntek

    (Corvinus University of Budapest)

Abstract

Backround Guidelines for economic analyses of health care technologies require local input data for reimbursement decisions in the countries of Central and Eastern Europe (CEE). The aim of this study was to systematically review and analyse the available empirical studies using the EQ-5D instrument as a measure of the health-related quality of life (HRQoL) in patients with neurological diseases. Methods A systematic literature search was performed up to 1st April 2018 to identify relevant studies in eight selected CEE countries. Original articles reporting on studies of neurological diseases using the EQ-5D instrument were analysed. Results Thirty-six articles, describing the results of 38 samples of patients and a total of 13,005 patients were included in the review. Most studies were from Hungary (44.4%) and none from Romania or Slovakia. EQ-5D utility scores were reported in 33 (91.7%) articles. In multiple sclerosis (MS) being the most represented disease, the average utility scores ranged from 0.49 in Austria to 0.80 in Poland with a weighted average of 0.69. EQ VAS scores for MS ranged from 39 in Czech Republic to 72.0 in Poland, with weighted average of 59.1. MS patients, together with epilepsy and essential tremor patients, estimated their HRQoL among the highest. Conclusions EQ-5D research activity in neurology has been increasing through the years in studied CEE countries. There are clinical areas with the significant social burden, such as a migraine or meningitis, that are completely lacking data, other areas, such as stroke or epilepsy, with very scarce data.

Suggested Citation

  • Valentina Prevolnik Rupel & Marko Divjak & Zsombor Zrubka & Fanni Rencz & László Gulácsi & Dominik Golicki & Dagmara Mirowska-Guzel & Judit Simon & Valentin Brodszky & Petra Baji & Jakub Závada & Guen, 2019. "EQ-5D studies in nervous system diseases in eight Central and East European countries: a systematic literature review," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 20(1), pages 109-117, June.
    • Handle: RePEc:spr:eujhec:v:20:y:2019:i:1:d:10.1007_s10198-019-01068-9
    DOI: 10.1007/s10198-019-01068-9
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    1. Marianna Cavazza & Yllka Kodra & Patrizio Armeni & Marta Santis & Julio López-Bastida & Renata Linertová & Juan Oliva-Moreno & Pedro Serrano-Aguilar & Manuel Posada-de-la-Paz & Domenica Taruscio & Arr, 2016. "Social/economic costs and health-related quality of life in patients with Duchenne muscular dystrophy in Europe," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 17(1), pages 19-29, April.
    2. Gisela Kobelt & Jenny Berg & Peter Lindgren & Carlotta Plesnilla & Ulf Baumhackl & Thomas Berger & Harald Kolleger & Karl Vass, 2006. "Costs and quality of life of multiple sclerosis in Austria," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 7(2), pages 14-23, July.
    3. Gisela Kobelt & Jenny Berg & Peter Lindgren & Carlotta Plesnilla & Ulf Baumhackl & Thomas Berger & Harald Kolleger & Karl Vass, 2006. "Costs and quality of life of multiple sclerosis in Austria," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 7(02), pages 14-23, July.
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    More about this item

    Keywords

    Health-related quality of life; EQ-5D; Neurological diseases; Central and Eastern European countries;
    All these keywords.

    JEL classification:

    • I18 - Health, Education, and Welfare - - Health - - - Government Policy; Regulation; Public Health

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