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Internal validation of models with several interventions

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  • Afschin Gandjour
  • Amiram Gafni

Abstract

In cost-effectiveness analyses, models are used typically to synthesize the best available data and/or extrapolate beyond clinical trial data. Ideally, models should be validated both internally and externally. The purpose of this paper is to suggest a test for internal validation of models where several interventions for the same clinical indication are compared. To the best of our knowledge, such a specific test does not yet exist. There are four versions of the test, which consider the relationship between incremental downstream costs and effects in the case of a single or several endpoints. We apply two versions of the validation test to published cost-effectiveness analyses of physical activity programs and demonstrate internal validity of the model in one study and lack of internal validity of the model in the other study. Copyright Springer-Verlag Berlin Heidelberg 2013

Suggested Citation

  • Afschin Gandjour & Amiram Gafni, 2013. "Internal validation of models with several interventions," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 14(6), pages 901-909, December.
    • Handle: RePEc:spr:eujhec:v:14:y:2013:i:6:p:901-909
    DOI: 10.1007/s10198-012-0434-3
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    References listed on IDEAS

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    More about this item

    Keywords

    Cost-effectiveness analysis; Decision model; Validation; I1;
    All these keywords.

    JEL classification:

    • I1 - Health, Education, and Welfare - - Health

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