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Predictors of Adverse Drug Reaction-Related Hospitalisations Among People with Dementia: A Retrospective Case-Control Study

Author

Listed:
  • Anum Saqib Zaidi

    (University of Tasmania)

  • Gregory M. Peterson

    (University of Tasmania
    University of Canberra)

  • Colin M. Curtain

    (University of Tasmania)

  • Mohammed S. Salahudeen

    (University of Tasmania)

Abstract

Introduction Adverse drug reactions (ADRs) are common among people with dementia; however, little is known about the magnitude and predictors associated with ADR-related hospitalisation among these individuals. This study aimed to determine the magnitude, types, drugs implicated and predictors of ADRs associated with hospitalisation among people with dementia. Methods This retrospective case-control study analysed medical records of individuals aged ≥ 65 years with dementia admitted to major public hospitals in Tasmania, Australia, from July 2010 to July 2021. Adverse drug reactions and implicated drugs were identified using administrative data and cross-checked with hospital medical records, with consensus reached among the research team. Results Of the 7928 people admitted to hospital at least once within the study period, 1876 (23.7%) experienced at least one ADR-related hospitalisation. Of these, 300 case patients with 311 ADRs and 300 control patients were randomly selected. The most common types of ADRs were renal (acute kidney injury; AKI) (36.0%), followed by neuropsychiatric (17.6%), cardiovascular (16.0%) and haematological (13.1%). Diuretics, renin-angiotensin system (RAS) inhibitors and anti-thrombotics constituted the main implicated drug classes. The ADR-related hospitalisation was associated with: chronic kidney disease (CKD) (OR 8.00, 95% CI 2.63–24.28, p

Suggested Citation

  • Anum Saqib Zaidi & Gregory M. Peterson & Colin M. Curtain & Mohammed S. Salahudeen, 2024. "Predictors of Adverse Drug Reaction-Related Hospitalisations Among People with Dementia: A Retrospective Case-Control Study," Drug Safety, Springer, vol. 47(8), pages 771-781, August.
    • Handle: RePEc:spr:drugsa:v:47:y:2024:i:8:d:10.1007_s40264-024-01435-3
    DOI: 10.1007/s40264-024-01435-3
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    References listed on IDEAS

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    1. Mulugeta Tarekegn Angamo & Leanne Chalmers & Colin M. Curtain & Luke R. E. Bereznicki, 2016. "Adverse-Drug-Reaction-Related Hospitalisations in Developed and Developing Countries: A Review of Prevalence and Contributing Factors," Drug Safety, Springer, vol. 39(9), pages 847-857, September.
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