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Adverse-Drug-Reaction-Related Hospitalisations in Developed and Developing Countries: A Review of Prevalence and Contributing Factors

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  • Mulugeta Tarekegn Angamo

    (University of Tasmania)

  • Leanne Chalmers

    (University of Tasmania)

  • Colin M. Curtain

    (University of Tasmania)

  • Luke R. E. Bereznicki

    (University of Tasmania)

Abstract

Adverse drug reactions (ADRs) are one of the leading causes of hospital admissions and morbidity in developed countries and represent a substantial burden on healthcare delivery systems. However, there is little data available from low- and middle-income countries. This review compares the prevalence and characteristics of ADR-related hospitalisations in adults in developed and developing countries, including the mortality, severity and preventability associated with these events, commonly implicated drugs and contributing factors. A literature search was conducted via PubMed, Scopus, Web of Science, Embase, ProQuest and Google Scholar to find articles published in English from 2000 to 2015. Relevant observational studies were included. The median (with interquartile range [IQR]) prevalence of ADR-related hospitalisation in developed and developing countries was 6.3 % (3.3–11.0) and 5.5 % (1.1–16.9), respectively. The median proportions of preventable ADRs in developed and developing countries were 71.7 % (62.3–80.0) and 59.6 % (51.5–79.6), respectively. Similarly, the median proportions of ADRs resulting in mortality in developed and developing countries were 1.7 % (0.7–4.8) and 1.8 % (0.8–8.0), respectively. Commonly implicated drugs in both settings were antithrombotic, non-steroidal anti-inflammatory and cardiovascular drugs. Older age, female gender, number of medications, renal impairment and heart failure were reported to be associated with an increased risk for ADR-related hospitalisation in both settings while HIV/AIDS was implicated in developing countries only. The majority of ADRs were preventable in both settings, highlighting the importance of improving medication use, particularly in vulnerable patient groups such as the elderly, patients with multiple comorbidities and, in developing countries, patients with HIV/AIDS.

Suggested Citation

  • Mulugeta Tarekegn Angamo & Leanne Chalmers & Colin M. Curtain & Luke R. E. Bereznicki, 2016. "Adverse-Drug-Reaction-Related Hospitalisations in Developed and Developing Countries: A Review of Prevalence and Contributing Factors," Drug Safety, Springer, vol. 39(9), pages 847-857, September.
  • Handle: RePEc:spr:drugsa:v:39:y:2016:i:9:d:10.1007_s40264-016-0444-7
    DOI: 10.1007/s40264-016-0444-7
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    Cited by:

    1. Solomon Shiferaw Nadew & Kidanemariam G/Michael Beyene & Solomon Worku Beza, 2020. "Adverse drug reaction reporting practice and associated factors among medical doctors in government hospitals in Addis Ababa, Ethiopia," PLOS ONE, Public Library of Science, vol. 15(1), pages 1-19, January.
    2. Rike van Eekeren & Leàn Rolfes & Andries S. Koster & Lara Magro & Gurumurthy Parthasarathi & Hussain Al Ramimmy & Tim Schutte & Daisuke Tanaka & Eugène van Puijenbroek & Linda Härmark, 2018. "What Future Healthcare Professionals Need to Know About Pharmacovigilance: Introduction of the WHO PV Core Curriculum for University Teaching with Focus on Clinical Aspects," Drug Safety, Springer, vol. 41(11), pages 1003-1011, November.
    3. Anum Saqib Zaidi & Gregory M. Peterson & Colin M. Curtain & Mohammed S. Salahudeen, 2024. "Predictors of Adverse Drug Reaction-Related Hospitalisations Among People with Dementia: A Retrospective Case-Control Study," Drug Safety, Springer, vol. 47(8), pages 771-781, August.
    4. Cristina Monteiro & Beatriz Dias & Maria Vaz-Patto, 2021. "Headache as an Adverse Reaction to the Use of Medication in the Elderly: A Pharmacovigilance Study," IJERPH, MDPI, vol. 18(5), pages 1-11, March.
    5. Mulugeta Tarekegn Angamo & Colin Michael Curtain & Leanne Chalmers & Daniel Yilma & Luke Bereznicki, 2017. "Predictors of adverse drug reaction-related hospitalisation in Southwest Ethiopia: A prospective cross-sectional study," PLOS ONE, Public Library of Science, vol. 12(10), pages 1-17, October.

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