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Sirolimus and mTOR Inhibitors: A Review of Side Effects and Specific Management in Solid Organ Transplantation

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Listed:
  • Lee S. Nguyen

    (Sorbonne Université, AP-HP, INSERM
    Sorbonne Université)

  • Mathieu Vautier

    (Sorbonne Université)

  • Yves Allenbach

    (Sorbonne Université)

  • Noel Zahr

    (Sorbonne Université, AP-HP, INSERM)

  • Olivier Benveniste

    (Sorbonne Université)

  • Christian Funck-Brentano

    (Sorbonne Université, AP-HP, INSERM)

  • Joe-Elie Salem

    (Sorbonne Université, AP-HP, INSERM)

Abstract

Inhibitors of mechanistic target of rapamycin (mTOR inhibitors) are used as antiproliferative immunosuppressive drugs and have many clinical applications in various drug combinations. Experience in transplantation studies has been gained regarding the side effect profile of these drugs and the potential benefits and limitations compared with other immunosuppressive agents. This article reviews the adverse effects of mTOR inhibitors in solid organ transplantation, with special attention given to mechanisms hypothesized to cause adverse events and their management strategies.

Suggested Citation

  • Lee S. Nguyen & Mathieu Vautier & Yves Allenbach & Noel Zahr & Olivier Benveniste & Christian Funck-Brentano & Joe-Elie Salem, 2019. "Sirolimus and mTOR Inhibitors: A Review of Side Effects and Specific Management in Solid Organ Transplantation," Drug Safety, Springer, vol. 42(7), pages 813-825, July.
    • Handle: RePEc:spr:drugsa:v:42:y:2019:i:7:d:10.1007_s40264-019-00810-9
    DOI: 10.1007/s40264-019-00810-9
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    References listed on IDEAS

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    1. Jinyu Liu & Dong Liu & Juan Li & Lan Zhu & Chengliang Zhang & Kai Lei & Qiling Xu & Ruxu You, 2017. "Efficacy and Safety of Everolimus for Maintenance Immunosuppression of Kidney Transplantation: A Meta-Analysis of Randomized Controlled Trials," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-21, January.
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