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Cost effectiveness of insulin glargine plus oral antidiabetes drugs compared with premixed insulin alone in patients with type 2 diabetes mellitus in Canada

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  • Sandra Tunis
  • Luc Sauriol
  • Michael Minshall

Abstract

These findings should be interpreted within the context of a large degree of uncertainty and of several study limitations that include a single clinical trial as the source for primary treatment assumptions and a single province as the source for most cost inputs. Under current study assumptions and limitations, insulin glargine plus OADs was projected to be a cost-effective option, compared with premixed insulin only, for the treatment of insulin-naive patients with type 2 diabetes unresponsive to OADs. Additional work is needed to examine the generalizability of the findings to individual jurisdictions of the Canadian healthcare system. Copyright Adis Data Information BV 2010

Suggested Citation

  • Sandra Tunis & Luc Sauriol & Michael Minshall, 2010. "Cost effectiveness of insulin glargine plus oral antidiabetes drugs compared with premixed insulin alone in patients with type 2 diabetes mellitus in Canada," Applied Health Economics and Health Policy, Springer, vol. 8(4), pages 267-280, July.
    • Handle: RePEc:spr:aphecp:v:8:y:2010:i:4:p:267-280
    DOI: 10.2165/11535380-000000000-00000
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    References listed on IDEAS

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    1. Philip Clarke & Alastair Gray & Rury Holman, 2002. "Estimating Utility Values for Health States of Type 2 Diabetic Patients Using the EQ-5D (UKPDS 62)," Medical Decision Making, , vol. 22(4), pages 340-349, August.
    2. Elkan F. Halpern & Milton C. Weinstein & Maria G.M. Hunink & G. Scott Gazelle, 2000. "Representing Both First- and Second-order Uncertainties by Monte Carlo Simulation for Groups of Patients," Medical Decision Making, , vol. 20(3), pages 314-322, July.
    3. Elise Pelletier & Paula Smith & Kristina Boye & Derek Misurski & Sandra Tunis & Michael Minshall, 2008. "Direct medical costs for type 2 diabetes mellitus complications in the US commercial payer setting," Applied Health Economics and Health Policy, Springer, vol. 6(2), pages 103-112, July.
    4. Elisabeth Fenwick & Andrew Briggs, 2007. "Cost-Effectiveness Acceptability Curves in the Dock," Medical Decision Making, , vol. 27(2), pages 93-95, March.
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    Cited by:

    1. Asrul Akmal Shafie & Chin Hui Ng & Yui Ping Tan & Nathorn Chaiyakunapruk, 2017. "Systematic Review of the Cost Effectiveness of Insulin Analogues in Type 1 and Type 2 Diabetes Mellitus," PharmacoEconomics, Springer, vol. 35(2), pages 141-162, February.
    2. Xinyang Hua & Thomas Wai-Chun Lung & Andrew Palmer & Lei Si & William H. Herman & Philip Clarke, 2017. "How Consistent is the Relationship between Improved Glucose Control and Modelled Health Outcomes for People with Type 2 Diabetes Mellitus? a Systematic Review," PharmacoEconomics, Springer, vol. 35(3), pages 319-329, March.
    3. Véronique Raimond & Jean-Michel Josselin & Lise Rochaix, 2014. "HTA Agencies Facing Model Biases: The Case of Type 2 Diabetes," PharmacoEconomics, Springer, vol. 32(9), pages 825-839, September.

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