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Economic Analyses of Pathogen-Reduction Technologies in Blood Transfusion: A Systematic Literature Review

Author

Listed:
  • Patrick R. LaFontaine

    (Rutgers University)

  • Jing Yuan

    (Rutgers University)

  • Katherine M. Prioli

    (Rutgers University)

  • Priti Shah

    (Rutgers University)

  • Jay H. Herman

    (Thomas Jefferson University Hospital)

  • Laura T. Pizzi

    (Rutgers University)

Abstract

Background Technologies used in the processing of whole blood and blood component products, including pathogen reduction, are continuously being adopted into blood transfusion workflows to improve process efficiencies. However, the economic implications of these technologies are not well understood. With the advent of these new technologies and regulatory guidance on bacterial risk-control strategies, an updated systematic literature review on this topic was warranted. Objective The objective of this systematic literature review was to summarize the current literature on the economic analyses of pathogen-reduction technologies (PRTs). Methods A systematic literature review was conducted using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines to identify newly published articles in PubMed, MEDLINE Complete, and EconLit from 1 January 2000 to 17 July 2019 related to economic evaluations of PRTs. Only full-text studies in humans published in English were included in the review. Both budget-impact and cost-effectiveness studies were included; common outcomes included cost, quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratios (ICERs). Results The initial searches identified 433 original abstracts, of which 16 articles were included in the final data extraction and reporting. Seven articles presented cost-effectiveness analyses and nine assessed budget impact. The introduction of PRT increased overall costs, and ICER values ranged widely across cost-effectiveness studies, from below $US150,000/QALY to upwards of $US20,000,000/QALY. This wide range of results was due to a multitude of factors, including comparator selection, target patient population, and scenario analyses included. Conclusions Overall, the results of economic evaluations of bacterial risk-control strategies, regardless of mechanism, were highly dependent on the current screening protocols in place. The optimization of blood transfusion safety may not result in decisions made at the willingness-to-pay thresholds commonly seen in pharmaceutical evaluations. Given the critical public health role of blood products, and the potential safety benefits introduced by advancements, it is important to continue building this body of evidence with more transparency and data source heterogeneity. This updated literature review provides global context when making local decisions for the coverage of new and emerging bacterial risk-control strategies.

Suggested Citation

  • Patrick R. LaFontaine & Jing Yuan & Katherine M. Prioli & Priti Shah & Jay H. Herman & Laura T. Pizzi, 2021. "Economic Analyses of Pathogen-Reduction Technologies in Blood Transfusion: A Systematic Literature Review," Applied Health Economics and Health Policy, Springer, vol. 19(4), pages 487-499, July.
    • Handle: RePEc:spr:aphecp:v:19:y:2021:i:4:d:10.1007_s40258-020-00612-6
    DOI: 10.1007/s40258-020-00612-6
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    References listed on IDEAS

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    1. Alessandro Liberati & Douglas G Altman & Jennifer Tetzlaff & Cynthia Mulrow & Peter C Gøtzsche & John P A Ioannidis & Mike Clarke & P J Devereaux & Jos Kleijnen & David Moher, 2009. "The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-28, July.
    2. Katherine M. Prioli & Julie Katz Karp & Nina M. Lyons & Vera Chrebtow & Jay H. Herman & Laura T. Pizzi, 2018. "Economic Implications of Pathogen Reduced and Bacterially Tested Platelet Components: A US Hospital Budget Impact Model," Applied Health Economics and Health Policy, Springer, vol. 16(6), pages 889-899, December.
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