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Development of Conversion Functions Mapping the FACT-B Total Score to the EQ-5D-5L Utility Value by Three Linking Methods and Comparison with the Ordinary Least Square Method

Author

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  • Chun Fan Lee

    (The University of Hong Kong)

  • Raymond Ng

    (National Cancer Center)

  • Nan Luo

    (National University of Singapore)

  • Yin Bun Cheung

    (Duke-NUS Medical School
    Singapore Clinical Research Institute
    University of Tampere and Tampere University Hospital)

Abstract

Introduction Health-related quality-of-life (HRQoL) measures are commonly mapped to a value that represents a utility for economic evaluation via regression models, which may lead to shrinkage of the variance. Objectives This study aimed to develop and compare conversion functions that map the Functional Assessment of Cancer Therapy—Breast (FACT-B) total score to the EuroQoL 5-Dimensions, 5-Levels (EQ-5D-5L) utility value via four methods. Methods We used the HRQoL scores of 238 Singapore patients with breast cancer to develop the conversion function for the equipercentile, linear equating, mean rank and ordinary least squares (OLS) methods. We compared the distributions of the observed values and the four sets of mapped values and performed regression analyses to assess whether the association with risk factors was preserved by utility values derived from mapping. Results At baseline, the observed EQ-5D-5L utility value had a mean ± standard deviation (SD) of 0.820 ± 0.152, and 24.8% of the respondents attained a value of 1. The OLS method (mean 0.820; SD 0.112; proportion 0%) better agreed with the observed data than the equipercentile (mean 0.831; SD 0.152; proportion 23.5%), linear equating (mean 0.814; SD 0.145; proportion 11.8%) and mean rank method (mean 0.821; SD 0.147; proportion 23.9%). The significance of association was preserved for all parameters involved in the regression analyses by the equipercentile and linear equating methods, but the mean rank and OLS methods were inconsistent with the observed data for one and two parameters, respectively. Conclusion The problem of shrinkage in the variance occurred in the OLS method, but it provided an unbiased estimate for the mean and better agreement. Among the other three linking methods, the mean rank method better described the distribution, whereas the equipercentile and linear equating methods better assessed the association with risk factors.

Suggested Citation

  • Chun Fan Lee & Raymond Ng & Nan Luo & Yin Bun Cheung, 2018. "Development of Conversion Functions Mapping the FACT-B Total Score to the EQ-5D-5L Utility Value by Three Linking Methods and Comparison with the Ordinary Least Square Method," Applied Health Economics and Health Policy, Springer, vol. 16(5), pages 685-695, October.
  • Handle: RePEc:spr:aphecp:v:16:y:2018:i:5:d:10.1007_s40258-018-0404-8
    DOI: 10.1007/s40258-018-0404-8
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    References listed on IDEAS

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    1. Aki Tsuchiya & Shunya Ikeda & Naoki Ikegami & Shuzo Nishimura & Ikuro Sakai & Takashi Fukuda & Chisato Hamashima & Akinori Hisashige & Makoto Tamura, 2002. "Estimating an EQ‐5D population value set: the case of Japan," Health Economics, John Wiley & Sons, Ltd., vol. 11(4), pages 341-353, June.
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    1. Clara Mukuria & Donna Rowen & Sue Harnan & Andrew Rawdin & Ruth Wong & Roberta Ara & John Brazier, 2019. "An Updated Systematic Review of Studies Mapping (or Cross-Walking) Measures of Health-Related Quality of Life to Generic Preference-Based Measures to Generate Utility Values," Applied Health Economics and Health Policy, Springer, vol. 17(3), pages 295-313, June.

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