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Approximate tail probabilities of the maximum of a chi-square field on multi-dimensional lattice points and their applications to detection of loci interactions

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  • Satoshi Kuriki
  • Yoshiaki Harushima
  • Hironori Fujisawa
  • Nori Kurata

Abstract

In this study, we define a chi-square random field on a multi-dimensional lattice points index set with a direct product covariance structure and consider the distribution of the maximum of this random field. We provide two approximate formulas for the upper tail probability of the distribution based on nonlinear renewal theory and an integral-geometric approach called the volume-of-tube method. This study is motivated by the detection problem of the interactive loci pairs which play an important role in forming biological species. The joint distribution of scan statistics for detecting the pairs is regarded as the chi-square random field above, and hence the multiplicity-adjusted $$p$$ p -value can be calculated using the proposed approximate formulas. By using these formulas, we examine the data of Mizuta, Harushima and Kurata (Proc Nat Acad Sci USA 107(47):20417–20422, 2010 ) who reported a new interactive loci pair of rice inter-subspecies. Copyright The Institute of Statistical Mathematics, Tokyo 2014

Suggested Citation

  • Satoshi Kuriki & Yoshiaki Harushima & Hironori Fujisawa & Nori Kurata, 2014. "Approximate tail probabilities of the maximum of a chi-square field on multi-dimensional lattice points and their applications to detection of loci interactions," Annals of the Institute of Statistical Mathematics, Springer;The Institute of Statistical Mathematics, vol. 66(4), pages 725-757, August.
  • Handle: RePEc:spr:aistmt:v:66:y:2014:i:4:p:725-757
    DOI: 10.1007/s10463-013-0419-8
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    References listed on IDEAS

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    1. David Siegmund, 2004. "Model selection in irregular problems: Applications to mapping quantitative trait loci," Biometrika, Biometrika Trust, vol. 91(4), pages 785-800, December.
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