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Health status and quality of life in comorbid physical multimorbidity and depression among adults aged ⩾50 years from low- and middle-income countries

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  • Mireia Felez-Nobrega
  • Ai Koyanagi

Abstract

Background: Data on the clinical and functional significance of comorbid depression in physical multimorbidity in middle-aged and older adults and from low- and middle-income countries (LMICs) are lacking. Aims: This study aims to determine the association of comorbid depression in physical multimorbidity with health outcomes and quality of life among adults aged ⩾50 years from six LMICs. Methods: Cross-sectional, nationally representative data from the Study on Global Ageing and Adult Health were analyzed. DSM-IV Depression was based on past 12-month symptoms. Eleven chronic physical conditions were assessed. Health status was based on scales ranging from 0 (best) to 100 (worse). The quality of life (8-item WHO Quality of Life) scale ranged from 0 (worse) to 100 (best). Multivariable linear regression analyses were conducted. Results: Data on 34,129 individuals aged ⩾50 years [mean (SD) age 62.4 (16.0) years; 52.1% females] were analyzed. Among people with physical multimorbidity, having comorbid depression was associated with significantly worse health status in terms of sleep/energy (β = 14.71: 95% CI [12.23, 17.20]), self-care (13.23: [8.66, 17.82]), pain/discomfort (13.03: [9.59, 16.47]), mobility (11.06: [6.91, 15.21]), cognition (10.41: [7.31, 13.50]), perceived stress (8.35: [4.71, 11.99]), interpersonal activities (7.81: [3.71, 11.91]), and lower quality of life (−8.81: [−10.74, −6.88]). Conclusions: Comorbid depression in physical multimorbidity was associated with lower quality of life and poorer scores in multiple domains of health status. Treatment of depression in people with physical multimorbidity may potentially lead to better clinical outcomes, but future studies are needed to determine the most effective intervention to address this comorbidity in LMICs.

Suggested Citation

  • Mireia Felez-Nobrega & Ai Koyanagi, 2023. "Health status and quality of life in comorbid physical multimorbidity and depression among adults aged ⩾50 years from low- and middle-income countries," International Journal of Social Psychiatry, , vol. 69(5), pages 1250-1259, August.
    • Handle: RePEc:sae:socpsy:v:69:y:2023:i:5:p:1250-1259
    DOI: 10.1177/00207640231157253
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    References listed on IDEAS

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    1. Ruimin Ma & Eugenia Romano & Davy Vancampfort & Joseph Firth & Brendon Stubbs & Ai Koyanagi & Deborah S Carr, 2021. "Physical Multimorbidity and Social Participation in Adult Aged 65 Years and Older From Six Low- and Middle-Income Countries," The Journals of Gerontology: Series B, The Gerontological Society of America, vol. 76(7), pages 1452-1462.
    2. Ellen E Freeman & Marie-Hélène Roy-Gagnon & Elodie Samson & Slim Haddad & Marie-Josée Aubin & Claudia Vela & Maria Victoria Zunzunegui, 2013. "The Global Burden of Visual Difficulty in Low, Middle, and High Income Countries," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-8, May.
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