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Exploring the Impact of Adding a Respiratory Dimension to the EQ-5D-5L

Author

Listed:
  • Martine Hoogendoorn

    (Institute for Medical Technology Assessment, Erasmus University, Rotterdam, Zuid-Holland, the Netherlands)

  • Mark Oppe

    (Executive Office, EuroQol Research Foundation, Rotterdam, Zuid-Holland, the Netherlands)

  • Melinde R. S. Boland

    (Erasmus School of Health Policy and Management, Erasmus University, Rotterdam, Zuid-Holland, the Netherlands)

  • Lucas M. A. Goossens

    (Erasmus School of Health Policy and Management, Erasmus University, Rotterdam, Zuid-Holland, the Netherlands)

  • Elly A. Stolk

    (Executive Office, EuroQol Research Foundation, Rotterdam, Zuid-Holland, the Netherlands)

  • Maureen P. M. H. Rutten–van Mölken

    (Institute for Medical Technology Assessment, Erasmus University, Rotterdam, Zuid-Holland, the Netherlands
    Erasmus School of Health Policy and Management, Erasmus University, Rotterdam, Zuid-Holland, the Netherlands)

Abstract

Objectives. To evaluate the impact of adding a respiratory dimension (a bolt-on dimension) to the EQ-5D-5L health state valuations. Methods. Based on extensive regression and principal component analyses, 2 respiratory bolt-on candidates were formulated: R1, limitations in physical activities due to shortness of breath, and R2, breathing problems. Valuation interviews for the selected bolt-ons were performed with a representative sample from the Dutch general public using the standardized interview protocol and software of the EuroQol group. Hybrid models based on the combined time-tradeoff (TTO) and discrete choice experiment (DCE) data were estimated to assess whether the 5 levels of the respiratory bolt-on led to significant changes in utility values. Results. For each bolt-on candidate, slightly more than 200 valuation interviews were conducted. Mean TTO values and DCE choice probabilities for health states with a level 4 or 5 for the respiratory dimension were significantly lower compared with the same health states in the Dutch EQ-5D-5L valuation study without the respiratory dimension. Results of hybrid models showed that for the bolt-on “limitations in physical activities,†the utility decrements were significant for level 3 (–0.055), level 4 (–0.087), and level 5 (–0.135). For “breathing problems,†the utility decrements for the same levels were greater (–0.086, –0.219, and –0.327, respectively). Conclusions. The addition of each of the 2 respiratory bolt-ons to the EQ-5D-5L had a significant effect on the valuation of health states with severe levels for the bolt-on. The bolt-on dimension “breathing problems†showed the greatest utility decrements and therefore seems the most appropriate respiratory bolt-on dimension.

Suggested Citation

  • Martine Hoogendoorn & Mark Oppe & Melinde R. S. Boland & Lucas M. A. Goossens & Elly A. Stolk & Maureen P. M. H. Rutten–van Mölken, 2019. "Exploring the Impact of Adding a Respiratory Dimension to the EQ-5D-5L," Medical Decision Making, , vol. 39(4), pages 393-404, May.
    • Handle: RePEc:sae:medema:v:39:y:2019:i:4:p:393-404
    DOI: 10.1177/0272989X19847983
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    References listed on IDEAS

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    1. Arthur E. Attema & Matthijs M. Versteegh & Mark Oppe & Werner B. F. Brouwer & Elly A. Stolk, 2013. "Lead Time Tto: Leading To Better Health State Valuations?," Health Economics, John Wiley & Sons, Ltd., vol. 22(4), pages 376-392, April.
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    Cited by:

    1. Haode Wang & Donna L. Rowen & John E. Brazier & Litian Jiang, 2023. "Discrete Choice Experiments in Health State Valuation: A Systematic Review of Progress and New Trends," Applied Health Economics and Health Policy, Springer, vol. 21(3), pages 405-418, May.
    2. Koonal K. Shah & Bryan Bennett & Andrew Lenny & Louise Longworth & John E. Brazier & Mark Oppe & A. Simon Pickard & James W. Shaw, 2021. "Adapting preference-based utility measures to capture the impact of cancer treatment-related symptoms," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 22(8), pages 1301-1309, November.
    3. Finch, Aureliano Paolo & Mulhern, Brendan, 2022. "Where do measures of health, social care and wellbeing fit within a wider measurement framework? Implications for the measurement of quality of life and the identification of bolt-ons," Social Science & Medicine, Elsevier, vol. 313(C).

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