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Derivation of Background Mortality by Smoking and Obesity in Cancer Simulation Models

Author

Listed:
  • Y. Claire Wang
  • Barry I. Graubard
  • Marjorie A. Rosenberg
  • Karen M. Kuntz
  • Ann G. Zauber
  • Lisa Kahle
  • Clyde B. Schechter
  • Eric J. Feuer

Abstract

Background. Simulation models designed to evaluate cancer prevention strategies make assumptions on background mortality—the competing risk of death from causes other than the cancer being studied. Researchers often use the U.S. life tables and assume homogeneous other-cause mortality rates. However, this can lead to bias because common risk factors such as smoking and obesity also predispose individuals for deaths from other causes such as cardiovascular disease. Methods. We obtained calendar year-, age-, and sex-specific other-cause mortality rates by removing deaths due to a specific cancer from U.S. all-cause life tables. Prevalence across 12 risk factor groups (3 smoking [never, past, and current smoker] and 4 body mass index [BMI] categories [

Suggested Citation

  • Y. Claire Wang & Barry I. Graubard & Marjorie A. Rosenberg & Karen M. Kuntz & Ann G. Zauber & Lisa Kahle & Clyde B. Schechter & Eric J. Feuer, 2013. "Derivation of Background Mortality by Smoking and Obesity in Cancer Simulation Models," Medical Decision Making, , vol. 33(2), pages 176-197, February.
  • Handle: RePEc:sae:medema:v:33:y:2013:i:2:p:176-197
    DOI: 10.1177/0272989X12458725
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    Cited by:

    1. Oguzhan Alagoz & Mehmet Ali Ergun & Mucahit Cevik & Brian L. Sprague & Dennis G. Fryback & Ronald E. Gangnon & John M. Hampton & Natasha K. Stout & Amy Trentham-Dietz, 2018. "The University of Wisconsin Breast Cancer Epidemiology Simulation Model: An Update," Medical Decision Making, , vol. 38(1_suppl), pages 99-111, April.

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