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The Cost-Effectiveness of Fluconazole Prophylaxis against Primary Systemic Fungal Infections in AIDS Patients

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  • Julie A. Scharfstein
  • A. David Paltiel
  • Kenneth A. Freedberg

Abstract

Objective. To project the cost-effectiveness of fluconazole for prophylaxis against AIDS-related primary systemic fungal infections. Design. A Markov model with data from the literature. Patients. Hypothetical cohort of 100,000 AIDS patients. Intervention. No prophylaxis, and fluconazole prophylaxis beginning when a patient's CD4 count declined to below 200/mm 3 , below 100/mm 3 , or below 50/mm 3 . Results. The no-pro phylaxis policy was associated with a discounted life expectancy of 28.20 months and direct medical costs of $36,100 per person. The

Suggested Citation

  • Julie A. Scharfstein & A. David Paltiel & Kenneth A. Freedberg, 1997. "The Cost-Effectiveness of Fluconazole Prophylaxis against Primary Systemic Fungal Infections in AIDS Patients," Medical Decision Making, , vol. 17(4), pages 373-381, October.
    • Handle: RePEc:sae:medema:v:17:y:1997:i:4:p:373-381
    DOI: 10.1177/0272989X9701700402
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    Cited by:

    1. James G. Kahn & Margaret L. Brandeau & John Dunn-Mortimer, 1998. "OR Modeling and AIDS Policy: From Theory to Practice," Interfaces, INFORMS, vol. 28(3), pages 3-22, June.
    2. Romain Micol & Ayden Tajahmady & Olivier Lortholary & Suna Balkan & Catherine Quillet & Jean-Philippe Dousset & Hak Chanroeun & Yoann Madec & Arnaud Fontanet & Yazdan Yazdanpanah, 2010. "Cost-Effectiveness of Primary Prophylaxis of AIDS Associated Cryptococcosis in Cambodia," PLOS ONE, Public Library of Science, vol. 5(11), pages 1-8, November.
    3. Joseph N Jarvis & Thomas S Harrison & Stephen D Lawn & Graeme Meintjes & Robin Wood & Susan Cleary, 2013. "Cost Effectiveness of Cryptococcal Antigen Screening as a Strategy to Prevent HIV-Associated Cryptococcal Meningitis in South Africa," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-9, July.

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