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Cost Effectiveness of Cryptococcal Antigen Screening as a Strategy to Prevent HIV-Associated Cryptococcal Meningitis in South Africa

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  • Joseph N Jarvis
  • Thomas S Harrison
  • Stephen D Lawn
  • Graeme Meintjes
  • Robin Wood
  • Susan Cleary

Abstract

Objectives: Cryptococcal meningitis (CM)-related mortality may be prevented by screening patients for sub-clinical cryptococcal antigenaemia (CRAG) at antiretroviral-therapy (ART) initiation and pre-emptively treating those testing positive. Prior to programmatic implementation in South Africa we performed a cost-effectiveness analysis of alternative preventive strategies for CM. Design: Cost-effectiveness analysis. Methods: Using South African data we modelled the cost-effectiveness of four strategies for patients with CD4 cell-counts

Suggested Citation

  • Joseph N Jarvis & Thomas S Harrison & Stephen D Lawn & Graeme Meintjes & Robin Wood & Susan Cleary, 2013. "Cost Effectiveness of Cryptococcal Antigen Screening as a Strategy to Prevent HIV-Associated Cryptococcal Meningitis in South Africa," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-9, July.
    • Handle: RePEc:plo:pone00:0069288
    DOI: 10.1371/journal.pone.0069288
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    References listed on IDEAS

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    1. Síle F Molloy & Tom Chiller & Gregory S Greene & Jessica Burry & Nelesh P Govender & Cecilia Kanyama & Sayoki Mfinanga & Sokoine Lesikari & Yacouba N Mapoure & Charles Kouanfack & Victor Sini & Elvis , 2017. "Cryptococcal meningitis: A neglected NTD?," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 11(6), pages 1-7, June.

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