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Serum uric acid level and all-cause and cardiovascular mortality in peritoneal dialysis patients: A systematic review and dose-response meta-analysis of cohort studies

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  • Ting Kang
  • Youchun Hu
  • Xuemin Huang
  • Adwoa N Amoah
  • Quanjun Lyu

Abstract

Background: The association between serum uric acid (SUA) and all-cause and cardiovascular disease (CVD) mortality in peritoneal dialysis (PD) patients is controversial. Therefore, we aimed to determine the relationship between SUA and all-cause and CVD mortality in PD patients. Method: Web of Science, EMBASE, PubMed and the Cochrane Library databases were searched from their inception to 7 April 2021. Effect estimates were presented as hazard ratios (HRs) with 95% confidence intervals (95% CIs) and pooled using random effects model. Result: Thirteen cohort studies with 22418 patients were included in this systematic review, of which 9 were included in the meta-analysis. Before switching the reference group, pooled result for the highest SUA category was significantly greater than the median for all-cause mortality (HR = 2.41, 95% CI: 1.37–4.26). After switching the reference group, the highest SUA category did not demonstrate an increased all-cause (HR = 1.40, 95% CI: 0.95–2.05) or CVD (HR = 1.30, 95% CI: 0.72–2.34) mortality compared with the lowest SUA category. Dose-response analysis suggested a nonlinear association between SUA and all-cause mortality risk (Pnonlinearity = 0.002). Conclusion: This meta-analysis didn’t find the relationship between SUA levels and all-cause and CVD mortality risk in PD patients. More rigorously designed studies are warranted in the future.

Suggested Citation

  • Ting Kang & Youchun Hu & Xuemin Huang & Adwoa N Amoah & Quanjun Lyu, 2022. "Serum uric acid level and all-cause and cardiovascular mortality in peritoneal dialysis patients: A systematic review and dose-response meta-analysis of cohort studies," PLOS ONE, Public Library of Science, vol. 17(2), pages 1-21, February.
    • Handle: RePEc:plo:pone00:0264340
    DOI: 10.1371/journal.pone.0264340
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    References listed on IDEAS

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    1. Peng Ju Liu & Fang Ma & Qi Yan Wang & Shu Li He, 2018. "The effects of oral nutritional supplements in patients with maintenance dialysis therapy: A systematic review and meta-analysis of randomized clinical trials," PLOS ONE, Public Library of Science, vol. 13(9), pages 1-17, September.
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