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The effects of oral nutritional supplements in patients with maintenance dialysis therapy: A systematic review and meta-analysis of randomized clinical trials

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  • Peng Ju Liu
  • Fang Ma
  • Qi Yan Wang
  • Shu Li He

Abstract

Background/objective: This systematic review aims to determine the potential effects of oral nutritional supplements (ONS) in patients receiving maintenance dialysis therapy (MDT). Methods: Electronic databases were searched without language limits through to July 2018. Randomized controlled trials (RCTs) that involved comparisons of ONS versus placebo or routine care are included in this meta-analysis. RevMan 5.3 statistical software was used for meta-analysis. Results: 15 articles with 589 subjects were included in our study. There are insufficient comparable data of randomized trials to allow meta-analysis of mortality. Albumin levels may be improved by the macronutrient blends or protein/amino acid supplements in MDT patients. Compared with the control group, serum albumin levels and BMI in the ONS group were increased by 1.58 g/L (95% CI, 0.52–2.63, P = 0.003; I2 = 85%) and 0.40 kg/m2 (95% CI, 0.10–0.71, P = 0.01; I2 = 49%), respectively. In the subgroup analysis of patients receiving hemodialysis, albumin levels in ONS group were increased by 2.17 g/L (95% CI, 0.89–3.45, P

Suggested Citation

  • Peng Ju Liu & Fang Ma & Qi Yan Wang & Shu Li He, 2018. "The effects of oral nutritional supplements in patients with maintenance dialysis therapy: A systematic review and meta-analysis of randomized clinical trials," PLOS ONE, Public Library of Science, vol. 13(9), pages 1-17, September.
    • Handle: RePEc:plo:pone00:0203706
    DOI: 10.1371/journal.pone.0203706
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    References listed on IDEAS

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    1. Jing Liu & Xiaoxi Zeng & Hyokyoung G Hong & Yi Li & Ping Fu, 2017. "The association between body mass index and mortality among Asian peritoneal dialysis patients: A meta-analysis," PLOS ONE, Public Library of Science, vol. 12(2), pages 1-14, February.
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    Cited by:

    1. Ting Kang & Youchun Hu & Xuemin Huang & Adwoa N Amoah & Quanjun Lyu, 2022. "Serum uric acid level and all-cause and cardiovascular mortality in peritoneal dialysis patients: A systematic review and dose-response meta-analysis of cohort studies," PLOS ONE, Public Library of Science, vol. 17(2), pages 1-21, February.

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