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Patient-reported outcomes among people living with HIV on single- versus multi-tablet regimens: Data from a real-life setting

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  • Sophie Degroote
  • Linos Vandekerckhove
  • Dirk Vogelaers
  • Charlotte Vanden Bulcke

Abstract

Background: The use of single-tablet regimens (STRs) in HIV treatment is ubiquitous. However, reintroducing the (generic) components as multi-tablet regimens (MTRs) could be an interesting cost-reducing strategy. It is essential to involve patient-reported outcome measures (PROs) to examine the effects of such an approach. Hence, this study compared PROs of people living with HIV taking an STR versus a MTR in a real world setting. Materials and methods: This longitudinal study included 188 people living with HIV. 132 remained on a MTR and 56 switched to an STR. At baseline, months 1-3-6-12-18 and 24, participants filled in questionnaires on health-related quality of life (HRQoL), depressive symptoms, HIV symptoms, neurocognitive complaints (NCC), treatment satisfaction and adherence. Generalized linear mixed models and generalized estimation equations mixed models were built. Results: Clinical parameters and PROs of the two groups were comparable at baseline. Neurocognitive complaints and treatment satisfaction did differ over time among the groups. In the STR-group, the odds of having NCC increased monthly by 4,1% as compared to the MTR-group (p = 0.035). Moreover, people taking an STR were more satisfied with their treatment after 6 months: the median change score was high: 24 (IQR 7,5–29). Further, treatment satisfaction showed a contrary evolution in the groups: the estimated state score of the STR-group increased by 3,3 while it decreased by 0,2 in the MTR-group (p = 0.003). No differences over time between the groups were observed with regard to HRQoL, HIV symptoms, depressive symptoms and adherence. Conclusions: Neurocognitive complaints were more frequently reported among people on an STR versus MTR. This finding contrasts with the higher treatment satisfaction in the STR-group over time. The long-term effects of both PROs should guide the decision-making on STRs vs. (generic) MTRs.

Suggested Citation

  • Sophie Degroote & Linos Vandekerckhove & Dirk Vogelaers & Charlotte Vanden Bulcke, 2022. "Patient-reported outcomes among people living with HIV on single- versus multi-tablet regimens: Data from a real-life setting," PLOS ONE, Public Library of Science, vol. 17(1), pages 1-15, January.
    • Handle: RePEc:plo:pone00:0262533
    DOI: 10.1371/journal.pone.0262533
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    1. Laurent Cotte & Tristan Ferry & Pascal Pugliese & Marc-Antoine Valantin & Clotilde Allavena & André Cabié & Isabelle Poizot-Martin & David Rey & Claudine Duvivier & Antoine Cheret & Pierre Dellamonica, 2017. "Effectiveness and tolerance of single tablet versus once daily multiple tablet regimens as first-line antiretroviral therapy - Results from a large french multicenter cohort study," PLOS ONE, Public Library of Science, vol. 12(2), pages 1-12, February.
    2. Donna E. Sweet & Frederick L. Altice & Calvin J. Cohen & Björn Vandewalle, 2016. "Cost-Effectiveness of Single- Versus Generic Multiple-Tablet Regimens for Treatment of HIV-1 Infection in the United States," PLOS ONE, Public Library of Science, vol. 11(1), pages 1-19, January.
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